Klozapin'in bizmut kaplı camsı karbon elektrotta ilaç dozaj formlarından miktarının belirlenmesi
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hitit Üniversitesi Fen Bilimleri Enstitüsü
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, Klozapin adlı etken maddenin, elektrokimyasal yükseltgenme özelliğinden faydalanarak modifiye camsı karbon elektrotta, ticari formundan miktarı belirlendi. Optimum şartları belirlemek için, farklı destek elektrolitlerde Diferansiyel Puls Voltametrisi (DPV) ve Dönüşümlü Voltametri (CV) ile yükseltgenme özelliği incelendi. Camsı karbon elektrot, BiCl3 çözeltisi ile modifiye edildi. Klozapin için modifiye camsı karbon elektrotta maksimum akımın gözlendiği pH=5,00 asetat tamponu çözeltisi, destek elektrolit olarak seçildi. Klozapin’in pik akımına ve pik potansiyeline pH’ın etkisi incelendi. Alt tayin sınırı (LOQ), tespit sınırı (LOD) ve derişim aralığı gibi analitik parametreler belirlendikten sonra ilaç tabletlerindeki Klozapin miktarı belirlendi. Uygulanan voltametrik tekniğin, doğruluk ve kesinliğini kontrol etmek amacı ile ilaç tabletinden Klozapin’in geri kazanım çalışmaları yapıldı. Ayrıca Klozapin’in yükseltgenme mekanizması önerildi.
In this study, active compounds named Clozapine was determined from commercial drug form based on electrochemical oxidation properties at modified glassy carbon electrode. In different supporting electrolyte, oxidation was examined by Differantial Pulse Voltammetry (DPV) and Cyclic Voltammetry (CV) to determine the optimum conditions. Glassy carbon electrode was modified with BiCl3 solution. pH=5.00 acetate buffer solution in which maxium current was observed, at glassy carbon electrode for Clozapine, was selected as supporting electrolyte. The effects of pH on the peak current and peak potential for material was examined and the impact of scan rate on the peak current was investigated. After analytical parameters, such as; limit of quantitation (LOQ), limit of detection (LOD) and range of concentration, had been determined, quantitative of Clozapine was determined from drug tablets. In order to check accuracy and precision of applied voltammetric method, recovery experiment of Clozapine was carried out from the drug tablet. Further more, oxidation mechanism of Clozapine was proposed.
In this study, active compounds named Clozapine was determined from commercial drug form based on electrochemical oxidation properties at modified glassy carbon electrode. In different supporting electrolyte, oxidation was examined by Differantial Pulse Voltammetry (DPV) and Cyclic Voltammetry (CV) to determine the optimum conditions. Glassy carbon electrode was modified with BiCl3 solution. pH=5.00 acetate buffer solution in which maxium current was observed, at glassy carbon electrode for Clozapine, was selected as supporting electrolyte. The effects of pH on the peak current and peak potential for material was examined and the impact of scan rate on the peak current was investigated. After analytical parameters, such as; limit of quantitation (LOQ), limit of detection (LOD) and range of concentration, had been determined, quantitative of Clozapine was determined from drug tablets. In order to check accuracy and precision of applied voltammetric method, recovery experiment of Clozapine was carried out from the drug tablet. Further more, oxidation mechanism of Clozapine was proposed.
Açıklama
Anahtar Kelimeler
Klozapin, Voltametrik Yöntem, Diferansiyel Puls Voltametrisi (DPV), Dönüşümlü Voltametri, Bizmut Kaplı Camsı Karbon Elektrot, Ticari İlaç Tabletleri
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Kurtoğu Yiğit, Ö. (2018). Klozapin'in bizmut kaplı camsı karbon elektrotta ilaç dozaj formlarından miktarının belirlenmesi (Yüksek Lisans Tezi).
