The effect of Blood Urea Nitrogen/Albumin Ratio in the Short-Term Prognosis of Chronic Obstructive Pulmonary Disease

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dc.contributor.authorBaha, Ayse Demir
dc.contributor.authorFendoglu, Turkan Zeynep Isikdogan
dc.contributor.authorKokturk, Nurdan
dc.contributor.authorKilic, Hatice
dc.contributor.authorHasanoglu, Hatice Canan
dc.contributor.authorArslan, Sertac
dc.contributor.authorAlhan, Aslihan
dc.date.accessioned2021-11-01T15:06:10Z
dc.date.available2021-11-01T15:06:10Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractObjective: There is no definite laboratory parameter in predicting short-term prognosis in patients with chronic obstructive pulmonary disease (COPD). Our aim was to evaluate the prognostic effect of serum blood urea nitrogen (BUN)/albumin ratio in COPD patients. Materials and Methods: A retrospective study comprising of 264 COPD patients who were in exacerbation period and selected from 4 centers was carried out. Data on demographic characteristics, disease characteristics, comorbid conditions and short-term prognosis of patients were obtained. and analyzed. Results: The BUN/Albumin ratio was higher in patients with oxygen saturation <90% (p=0.004). There was no difference between global obstructive lung disease (GOLD) stages means of BUN/Albumin ratio but this rate was higher in those with infective exacerbations (p=0.019). The BUN/albumin ratio of patients who were discharged (5.3 +/- 2.2) was significantly higher than the patients who were transferred to the intensive care unit [ICU] (11.7 +/- 6.0) (p<0.0001). The cut-off level of BUN/albumin ratio in prediction of the need for ICU was7.2 (sensitivity 80%, specificity 85.4%) and the area under the receiver operating characteristic (ROC) curve was 0.911 (95% CI: 0.861-0.961) (p<0.001). The cut-off level of BUN/albumin ratio in prediction of mortality was 8.1 (sensitivity 88.2%, specificity 85.4%) and the area under the ROC curve was 0.963 (95% CI: 0.930-0.995) (p<0.001). Conclusion: BUN/albumin ratio can be used as an affordable, inexpensive and practical method for determining the short-term prognosis in hospitalized COPD patients. Prospective studies involving more patients are needed.
dc.identifier.doi10.14744/etd.2020.13914
dc.identifier.endpage188en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue2en_US
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2020.13914
dc.identifier.urihttps://hdl.handle.net/11491/7506
dc.identifier.volume43en_US
dc.identifier.wosWOS:000626292700016
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherErciyes Univ Sch Medicine
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOPDen_US
dc.subjectbiomarkeren_US
dc.subjectBUN/albumin ratioen_US
dc.subjectprognosisen_US
dc.subjectmortalityen_US
dc.titleThe effect of Blood Urea Nitrogen/Albumin Ratio in the Short-Term Prognosis of Chronic Obstructive Pulmonary Disease
dc.typeArticle

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