Plasma preptin levels in patients with type 2 diabetes mellitus

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dc.contributor.authorKalaycı, Mehmet
dc.contributor.authorHalifeoğlu, İhsan
dc.contributor.authorKalaycı, Hatice
dc.contributor.authorUğur, Kader
dc.contributor.authorYılmaz, Musa
dc.date.accessioned2021-11-01T18:18:18Z
dc.date.available2021-11-01T18:18:18Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractObjectives: Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia, and the prevalence is rapidly increasing worldwide. Preptin is a novel molecule with a metabolic effect that is secreted from pancreatic beta cells along with insulin. There are currently few studies about preptin in patients with type 2 DM (T2DM). This study was designed to observe differences in the plasma preptin level in patients with T2DM in comparison with a control group. Methods: The study included 82 patients with T2DM (mean age: 49.00±5.97 years; 42 females, 40 males) and 65 healthy individuals (mean age: 41.98±5.62 years; 31 females, 34 males). The patients with T2DM were divided into 2 groups: those newly diagnosed and those previously diagnosed and in treatment. The previously diagnosed group was further separated into 2 groups based on their glycated hemoglobin (HbA1c) level: a well-controlled DM (HbA1C value <7%) group and a poorly controlled DM (HbA1C value >7%) group. The chemistry parameters were analyzed with an Advia 1800 analyzer (Siemens Healthineers, Erlangen, Germany), and hormonal parameters were analyzed with an Immulite 2000 analyzer (Siemens Healthineers, Erlangen, Germany). Plasma preptin levels were measured using the enzymelinked immunosorbent assay method. Results: Patients with newly or previously diagnosed T2DM had significantly higher glucose, HbA1c, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol, triglyceride, low-density lipoprotein cholesterol, and preptin values (p<0.001 for each), and significantly lower high-density lipoprotein cholesterol levels compared with the control group (p<0.001). The preptin level demonstrated a positive correlation with insulin, HOMA-IR, HbA1c, and glucose levels (for control group: r=0.452-p=0.000, r=0.472-p=0.000, r=0.389-p=0.001, r=0.286-p=0.021, respectively; for T2DM group: r=0.484-p=0.000, r=0.544-p=0.000, r=0.288-p=0.009, r=0.236-p=0.033, respectively). Conclusion: The observed correlation between preptin level and DM a suggests that this peptide may have a possible role in the pathogenesis of DM, which may be particularly valuable, given that DM is a major public health problem.
dc.identifier.endpage5en_US
dc.identifier.issn2587-2362
dc.identifier.issn2618-642X
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpNeE5qWTFOUT09
dc.identifier.urihttps://hdl.handle.net/11491/8000
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofInternational Journal of Medical Biochemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiyokimya ve Moleküler Biyolojien_US
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyolojien_US
dc.titlePlasma preptin levels in patients with type 2 diabetes mellitus
dc.typeArticle

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