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Öğe A study on distribution of cancer cases diagnosed in Çorum(Federation of Turkish Pathology Societies, 2014) Baş, Yılmaz; Uzbay, Pınar; Güney, Güven; Erenler, Behice Hande; Yılmaz, Dilek; Özdemir, ÇiğdemObjective: In order to help obtain accurate knowledge and to contribute to the establishment of data for regional tumor statistics, we aimed to determine the frequency distribution of cancer cases that was diagnosed in Çorum province. Material and Method: In this descriptive study, we retrospectively reviewed the archive records of the pathology departments' of one university hospital and two private hospitals serving in the province of Çorum. A total of 138,973 recorded pathology reports were reviewed. Metastatic cancers with a known primary source were excluded. A total of 2184 cases with a diagnosis of cancer were recorded by gender, age, and system/organ and classified to 10 most frequent types of cancer both in general and in terms of gender distribution. Results: The male to female ratio was 1.44 and the mean age was 64.26 years. The cancer is most commonly encountered between 70 and 79 years of age (35.27%) in males whereas the second most common interval was 60 to 69 years of age (23.88%). In females, the cancer is most commonly encountered between 70 and 79 years of age (24.16%) whereas the second most common interval was 60 to 69 years of age (22.60%). The top five cancers were skin (33.60%), prostate (13.87%), stomach (9.07%), urinary bladder (8.61%) and breast (7.88%). Conclusion: Distribution of organ/system involvement of cancer cases that were diagnosed in Çorum is quite different from the data regarding Turkey in general. Development of cancer registry centers, upgrading to an active registry system and having all cancer data from health institutions unified in a single organization are mandatory to achieve reliable data.Öğe Adverse effects of ingredients available in single nasal decongestant formulation at trachea and lungs on an experimental rat model(Discovery Publication, 2019) Arslan, Sertaç; Güney, Güven; Akyüz Ünsal, Ayşe İpek; Demir, Emre; Demirci, BuketBackground and Aim: There is little histologic data concerning effects of nasal decongestants on respiratory tract. We aimed to put forth the effects of mostly used ingredients of nasal decongestants on trachea and lower airways of rats. Materials and Method: Four-six months old 60 male rats were randomly categorized into 6 groups. Experimental drugs were applied to the same nostril twice daily for 8 weeks (Xylometazoline, Benzalkolyum, EDTA, Sorbitol and combined drug solution). Normal saline solution (NaCl % 0.9) applied for the controls. At the end, trachea and both lungs were dissected and kept in formaldehyde for histopathologic evaluation. Results: Inflammation and bronchial edema were most common findings. All rats in sorbitol group had increased numbers of type 2 pneumocytes. Eighty percent of BAC group had increased numbers of type 2 pneumocytes. Spillover of tracheal epithelium was seen mostly in sorbitol, EDTA and combined drug groups (60%, 87.5%, 50% respectively). Bronchial smooth muscle hypertrophy was seen mostly in BAC and EDTA group (70%, 62.5% respectively). Number of goblet cells showed significant difference between control-combined drug (p=0.025) and control-BAC (p=0.001) groups. Conclusion: Nasal decongestants might have adverse effects such as increased airway inflammation, edema, type 2 pneumocyte numbers and epithelial desquamation mostly.Öğe Colon perforation and Budd-Chiari syndrome in Behçet’s disease(Medical Science International, 2015) Baş, Yılmaz; Güney, Güven; Uzbay, Pınar; Zobacı, Ethem; Ardalı, Selin; Taylan Özkan, Hikmet AyşegülObjective: Unusual clinical course Background: Behçet’s disease is a chronic inflammatory disease involving multiple systems, with vasculitis being the most important pathological feature. Multiple colon perforations are thought to be secondary to vasculitis and they occur in patients with ulcers. These may be encountered within the entire colon but most commonly in the ileocecal region. Intestinal perforation and Budd-Chiari syndrome are infrequent in Behçet’s disease, and are associated with high mortality and morbidity. Budd-Chiari syndrome results from occlusion of either hepatic veins or adjacent inferior vena cava, or both. Case Report: We report a patient with Behçet’s disease having multiple perforations in the transverse colon, descending colon, and sigmoid colon. The patient also had Budd-Chiari syndrome due to inferior vena cava thrombosis extending into the right and middle hepatic vein. Our observations are presented with a review of the literature. Conclusions: In Behçet’s disease, treatment of colon perforation necessitates urgent surgery, whereas management of Budd- Chiari syndrome is directed towards the underlying cause. Behçet’s disease, as a chronic multisystemic disease with various forms of vasculitis, is resistant to medical and surgical treatment. Prognosis is worse in Behçet’s disease with colon perforation than that in Budd-Chiari syndrome alone. © Am J Case Rep, 2015.Öğe Comparison of effects of vessel-sealing devices and conventional hemorrhoidectomy on postoperative pain and quality of life(International Scientific Information, Inc., 2018) Kendirci, Murat; Şahiner, İbrahim Tayfun; Şahiner, Yeliz; Güney, GüvenBackground: The aim of this study was to investigate the early and late results of use of LigaSure, Harmonic Scalpel, and conventional hemorrhoidectomy in hemorrhoidectomy, to determine the least painful method, and to investigate the relationship between pain perception and personal differences in hemorrhoid bundles. Material/Methods: Ninety patients undergoing hemorrhoidectomy between 2014 and 2017 were retrospectively evaluated. We investigated the duration of hospitalization and the presence of bleeding, incontinence, perianal wetness, urinary retention, stenosis, and recurrence during follow-up after surgery. Analgesic requirement was determined by Patient-Controlled Analgesia, as well as pain score by use of the Visual Analog Score and patient satisfaction by Short Form-36. We also assessed the relationship between pain and lateral thermal damage, the number of peripheral nerves, number of excised bundles, and the number of thrombosed vessels, as determined by histopathological examination. Results: No differences were found among the 3 methods in the duration of hospitalization, the presence of bleeding, fecal incontinence, perianal wetness, urinal retention, anal stenosis, recurrence rate, VAS, analgesic consumption, or results of the SF-36. There was no difference in the number of bundles, thrombosed vessels, or number of nerve fibers in a bundle, but the LigaSure Hemorrhoidectomy had more lateral thermal damage (p<0.001). While there was a difference between VAS of day 1 and 7 according to the hemorrhoid bundles, there was no difference in the other parameters. Conclusions: There was no difference among the 3 methods in terms of complications, postoperative pain, or patient satisfaction, and pain intensity was positively correlated with the number of excised bundles. © Med Sci Monit.Öğe Dasatinib-induced severe hemorrhagic colitis in chronic myeloid leukemia(Akademi Doktorlar Yayınevi, 2016) Kekilli, Murat; Tanoğlu, Alpaslan; Kızıl Çakar, Merih; Güney, Güven; Haznedaroğlu, İbrahim C.Dear Editor, Dasatinib is an orally administered, potent, secondline tyrosine kinase inhibitor which is used for treating imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia.Öğe Distribution of cancer cases between January 01, 2014 and December 30, 2016 in Çorum city, Turkey(Türk Radyasyon Onkolojisi Derneği, 2017) Baş, Yılmaz; Erenler, Behice Hande; Güney, Güven; Turgal, Ebru; Keser, Havva Hande; Şahin, Şahatayi; Tunus, İbrahimOBJECTIVE This study aimed to investigate the frequency and distribution of adult cancer cases in Çorum city, Turkey. METHODS We retrospectively reviewed archive records and found 2204 cancer cases between January 01, 2014 and December 30, 2016 from the records of X University, Faculty of Medicine, Department of Pathology and City Public Health Directorate Cancer Department. RESULTS The mean age of the patients was 65.5 years. The male to female ratio was 1.40, and 41.7% (n=919) of the patients were females and 58.3% (n=1285) were males. The youngest patient was 18 years old and the oldest was 96 years old. The top ten cancers were skin (n=374, 17.0%), lung (n=205, 9.3%), colorectal (n=204, 9.3%), breast (n=192, 8.7%), prostate (n=174, 7.9%), stomach (n=173, 7.3%), urinary bladder (n=159, 7.2%), thyroid (n=136, 6.2%), uncertain primary (n=85, 3.9%), and pancreatic (n=82, 3.7%) cancers. CONCLUSION Development of cancer registry centers, upgrading to an active registry system, and obtaining all cancer data from health institutions and unifying it in a single organization are mandatory to achieve reliable data. Dissemination of screening methods is also important. As a result, determination of local cancer risk factors with the development of early diagnostic methods and the creation of cancer registration system will form the basis for future studies to be developed to prevent cancer.Öğe Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury(Turkish Neurosurgical Society, 2018) Şentürk, Salim; Yaman, Mesut Emre; Aydın, Hasan Emre; Güney, Güven; Bozkurt, İsmail; Paksoy, Kemal; Abdioğlu, Ahmet AtillaAIM: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI). MATERIAL and METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-?) and interleukin (IL)-1? were measured. RESULTS: The resveratrol group had statistically significant lower levels of TNF-?, IL -1?, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells. CONCLUSION: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects. © 2018 Turkish Neurosurgical Society.Öğe Geçirilmiş adenotonsillektomi öyküsü helicobacter pylori gastriti için koruyucu bir etken midir?(Bilimsel Tıp Yayınevi, 2019) Güney, Güven; Baş, Yılmaz; Kekilli, Murat; Demir, EmreGiriş: Helicobacter pylori tüm dünyada görülen, dünya nüfusunun yaklaşık yarısını etkileyen gram-negatif bir basildir. Yapılan çalışmalarda adenotonsiller bölgenin H. pylori için bir kolonizasyon alanı olduğu ve bulaşta etkili olduğu ileri sürülmüştür. Bu hipotezden hareketle, geçirilmiş adenotonsillektomi öyküsü (ATÖ)’nün midede H. pylori kolonizasyonu için koruyucu bir etken olabileceğini belirten çalışmalar mevcuttur. Bu çalışmamızda geçirilmiş ATÖ’nün H. pylori gastriti açısından koruyucu bir etken olup olmadığını belirlemeye çalıştık. Materyal ve Metod: Çalışmaya, Hitit Üniversitesi Çorum Erol Olçok Eğitim ve Araştırma Hastanesi Gastroenteroloji Kliniğine dispeptik şikayetlerle ilk kez başvuran ve antrumdan endoskopik biyopsi alınan (75’inde ATÖ olan, 75’inde ATÖ olmayan) toplam 150 hasta dahil edildi. Hastalardan alınan endoskopik biyopsiler hematoksilen eozin (HE) ve H. pylori varlığını saptamak için doku Giemsası ile boyanarak bütün olgular aynı patolog tarafından Sydney Update sistemine göre değerlendirildi. Bulgular: ATÖ olan hastaların yaşı 22-80 arasında değişmekte olup ortalaması 46.5 (± 17.5 SS) yıl iken, ATÖ olmayan grubun yaşları ise 24-75 yıl arasında değişmekte olup ortalaması 38.3 (± 14.0 SS) yıl idi. Yaş açısından saptanan fark istatistiksel olarak anlamlı bulunmuştur. ATÖ olmayan 75 hastanın 52 (%69)’sinde H. pylori gastriti saptanırken, ATÖ olan 33 (%44) hastada H. pylori gastriti saptanmış ve bu fark istatistiksel olarak anlamlı bulunmuştur (p= 0.021). Her iki gruptaki tüm hastaların dahil edildiği karşılaştırmada ATÖ öyküsü olmayan grupta H. pylori yoğunluğu ortalaması 1.6 iken, olan grupta H. pylori yoğunluğu ortalaması 0.8 olarak saptanmış ve bu fark istatistiksel olarak anlamlı bulunmuştur (p= 0.012). Her iki gruptaki sadece H. pylori gastriti saptanan hastalardaki H. pylori yoğunluğu karşılaştırıldığında ise ATÖ öyküsü olmayan grubun ortalaması 2.3 iken, olan grubun ortalaması 1.8 olarak saptanmış ve bu fark da istatistiksel olarak anlamlı bulunmuştur (p= 0.022). Sonuç: H. pylori için adenotonsiller bölgenin bir kolonizasyon alanı olduğu birçok çalışmada değişik yöntemler kullanılarak gösterilmiştir. Çalışmamızda ATÖ’nün bu bölgedeki kolonizasyonu engelleyeceği için H. pylori bulaşını azaltacağı ve H. pylori gastriti açısından koruyucu bir rol oynayabileceği sonucuna varılmıştır.Öğe Göz kapağı tümörlerinde histopatoloji sonuçları(Türkiye Klinikleri, 2017) Çağlar, İsmail Çağatay; Güney, Güven; Dönmez, Oya; Baş, Yılmaz; Durmuş, MustafaAmaç: Göz kapağı tümörlerinin demografik, klinik ve histopatolojik sonuçlarını değerlen-- dirmektir. Gereç ve Yöntemler: Aralık 2012--Ekim 2015 tarihleri arasında, Hitit Üniversitesi Eğitim ve Araştırma Hastanesinde göz kapağı tümörü nedeni ile ameliyat edilen hastaların kayıtları geriye dönük olarak incelendi. Yaş, cinsiyet, kitlenin yeri ve boyutu ile histopatolojik sonuçlar kaydedildi. Bulgular: Yaş ortalamaları 49,18:17,6 (3-95) yil olan 348'i kadın, 225'i erkek 573 hastanın 674 gözü çalışmaya dâhil edildi. Sık görülen iyi huylu göz kapağı tümörleri %20 oranla nevüs, %16,4 oranla seboreik keratoz ve %10,2 oranla ksantelezma idi. Kötü huylu göz kapağı tümörlerinin 29 (%82,8)'u bazal hücreli karsinom, (%11,4)'ü skuamöz hücreli karsinom, (%2,4)'i sebase bez karsinomu ve (%2,4)'i malign melanom idi. Melanositik nevüs, ksantelezma ve siringoma kadınlarda daha sıktı (p<0,001). Bazal ve skuamöz hücreli karsinom iyi huylu tümörlere göre yaşlılarda daha sık göz-- lemlendi (sırasıyla 65,86 ve 61,5 yaş). Pilomatriksoma ve molluskum kontagiozum gençlerde diğer iyi huylu tümörlere göre daha sıktı. Ortalama tümör boyutu 0,62:0,43 cm idi. Skuamöz hücreli karsinom bütün tümörler içinde en büyük boyutlara sahipti (1,6 cm). Sonuç: Çalışmamızda bölge-- mizde en sık görülen iyi huylu tümör nevüs, en sık görülen kötü huylu tümör ise bazal hücreli kar-- sinom olarak saptanmıştır.Öğe Histopathological findings after breast reduction operations with inferior Pedicular techniques(Discovery Publication, 2019) Muslu, Ümran; Şenen Demirez, Dilek; Güney, Güven; Şenel, EnginIntroduction: Breast reduction mammoplasty is one of the most commonly performed cosmetic surgical procedures, which provide us with breast tissue for pathologic examination. In this study, we aimed to examine the breast tissue to detect histopathological abnormalities. Material-Method: It is a single-center, retrospective study designed in Antalya Education and Research Hospital between 2011-2014. 276 patients were included in this study. All patients underwent bilateral breast reduction surgery. Mean age of the patients was 42.5 +/- 12.0 years (median: 43, min: 17, max: 75). The patients were examined psychically, and then mammography, ultrasonography and MRI (older than 40 years) and breast ultrasonography and MRI (younger than 40 years) were performed. No evidence of tumor formation was seen in any of the patients who were included in the study. Results: All mastectomy specimens were evaluated histopathologically (n=552). The lightest specimen was 183 g., the heaviest specimen weight was 2800 g. 114 breast specimens were histopathologically normal, nonproliferative lesions were found in 349 breast specimens. A slight increase in risk was seen in 80 specimens. 80 specimens were found to be moderately increased risk. None of the patients showed any significant increased risk. Only one lobular carcinoma was detected. Conclusion: According to our findings, it is important to examine breast tissues for the detection of breast lesions. Breast reduction surgery may be useful for not only cosmetic concerns but also detection of proliferative, nonproliferative lesions, and even carcinoma.Öğe Hitit Üniversitesi Eğitim ve Araştırma Hastanesi patoloji bölümünde tanısı konulan kanser olgularının dağılımı üzerine bir çalışma(Türkiye Klinikleri, 2015) Baş, Yılmaz; Keser, Havva Hande; Erenler, Behice Hande; Güney, Güven; Yılmaz, Dilek; Ateş, Deniz; Uzbay, PınarObjective: In this study, we aimed to investigate the frequency and distribution of cancer cases evaluating in the province in a certain time period, the number by age and gender, with university hospital pathology laboratory data at our city in Çorum. Material and Methods: Total of 372 cancer cases were diagnosed in our department between 01.05.2013-01.08.2014 at Hitit University, Education and Research Hospital. Types of cancer, the age and sex data were obtained from pathology reports and hospital records system. If necessary, patients and/or to communicate by phone with relatives. Results: 40.03% of patients were female (n=317), 59.97% were male (n=475). The youngest of the patients was 17 and the oldest was 92 years old. Average age was 65,01. According to the organ skin (n=160, 20.20%), prostate (n=90, 11.36%), colorectal (n=86, 10.86%), bladder (n=86, 10.86%), stomach (n=71, 8.98%), thyroid (n=59, 7.45%), breast (n=53, 6.69%), lung (n=32, 4.04%), uterine corpus (n=28, 3.53%), and oral cavity (n=24, 3.03%) cancers were the top ten most common cancers. Women most common skin (n=74, 22.70%), breast (n=53, 16.26%), thyroid (n=47, 14.42%), colorectal (n=34, 10.53%) and uterine corpus (n=28, %8.59) cancers for men prostate (n=90, 19.31%), skin (n=86, 18.45%), bladder (n=78, 16.74%), colorectal (n=52, 11.16%) and stomach (n=19, 10.94%) took the top five cancers. Conclusion: In this study, the skin in men, cancer of the urinary tract and gastrointestinal tract, skin, women, breast and thyroid cancers are the most common cancers. Making serious and extensive research on the etiology is required. The average life expectancy in the incidence of cancer in old age with an increase in elongation is observed. World and Turkey in our region with lung cancer, the most common reasons for non-compliance in general it is necessary to focus on the incidence of common cancers. Cervical cancer is not detected in this study. Screening methods may cause the spread of priority. As a result, the determination of local cancer risk factors with the development of early diagnostic methods, the creation of cancer registration system will form the basis for the project will be developed for the prevention of cancer. © 2015 by Türkiye Klinikleri.Öğe Malignancy rates of thyroid cytology: Cyst fluid benign or non-diagnostic?(International Scientific Information, Inc., 2017) Güney, Güven; Şahiner, İbrahim TayfunBackground: We sought to investigate subgroup distribution using Bethesda classification and risks for malignancy. We also compared the malignancy risk of cases that were denoted as non-diagnostic due to cystic contents, with cases that were denoted as non-diagnostic due to presence of other features. Material/Methods: The study included pathology test results of 1,440 thyroid nodule samples diagnosed using Bethesda classification. Results of 305 thyroidectomy excision specimens from these patients were also compared with cytology results to determine the frequency of malignancy. The non-diagnostic group was divided into two categories: those with cystic contents, and others. Malignancy rates were separately calculated for the two groups, and compared with the other classification groups. Results: Distribution of malignancy rates by Bethesda classification were as follows: non-diagnostic 12.5% (6/48), benign 1.5% (3/198), atypia of undetermined significance/follicular lesion of undetermined significance (AFLUS) 9% (1/11), suspicious for follicular neoplasm (SFN) 37.5% (3/8), suspicious malignancy 70% (8/26), malignancy 100% (14/14). Conclusions: Despite the limited number of cases, our study concluded that cystic content was closer to the benign category than the non-diagnostic category if the assessment was based on malignancy rates. In this group, similar to aspirations containing plenty of lymphocytes that indicates colloid or lymphocytic thyroiditis, it is still controversial whether criterion for adequacy of follicular epithelial cells should be sought, or if they should be regarded as benign in order to prevent unnecessarily performance of repeat aspirations. © Med Sci Monit.Öğe Molecular features of follicular variant papillary carcinoma of thyroid: comparison of areas with or without classical nuclear features(Humana Press Inc., 2013) Güney, Güven; Tezel, Gaye Güler; Kösemehmetoğlu, Kemal; Yılmaz, Engin; Balcı, Serdar; Ersoy, Reyhan; Çakır, Bekir; Güler, GülnurWe aimed to compare the genetic background of different areas in follicular variant papillary thyroid carcinomas (FVPTC) with or without classical nuclear changes. Sixteen cases of FVPTC were included in our study. All tumors were well demarcated from surrounding thyroid tissue and had both areas with nuclear features (WNF) and areas without nuclear features (WONF) of papillary carcinoma. DNA is obtained by laser microdissection from WNF and WONF areas of each case. Point mutations for NRAS codon 61, HRAS codon 61, and BRAF were investigated by direct sequencing. In 11 cases, reverse transcription PCR was performed for the presence of PAX8-PPAR? and RET/PTC1–3 gene rearrangements. Point mutation for NRAS codon 61 was also studied in 15 colloidal nodules. Seven cases (44 %) showed at least one mutation; two cases (13 %) revealed the same mutation in both WNF and WONF areas, while in the rest only WNF areas were mutated. None of the studied 11 cases demonstrated RET/PTC1–3 gene rearrangement and in only one case PAX8-PPAR? gene rearrangement was found. Six cases (38 %) showed NRAS codon 61 mutation, involving only WNF areas in five cases and both WNF and WONF areas in one case. Neither HRAS codon 61 nor BRAF mutations were present. Fifteen colloidal nodules were also wild type for NRAS codon 61. Our findings suggest that NRAS codon 61 point mutations and PAX8-PPAR? gene rearrangement play a role in the FVPTC pathogenesis and may be established before the morphological/phenotypical features fully develop. © 2013, Springer Science+Business Media New York.Öğe Nadir Görülen Benign Akciğer Kitlesi: Endobronşial Lipom(2021) Arslan, Sertaç; Arı Yılmaz, Yasemin; Onaran Boyacı, Hilal; Güney, Güven; Gülhan, MeralAkciğerin benign tümörleri nadir görülmektedir. Endobronşiyal Lipom akciğerin çok nadir görülen benign bir tümörüdür. Yavaş büyüme gösteren bu tümör bronş obstrüksiyonuna neden olarak postobstüktif pnömoni, kalıcı parankim hasarı gibi patolojilere yol açabilmektedir. Bununla birlikte bu olgular astım, kronik bronşit gibi yanlış tanılarla uzun süre izlenebilmektedir. Kronik öksürük nedeniyle başvuran ve bronkoskopik biyopsi ile tanı konulan akciğerin nadir görülen benign tümörü olan Endobronşiyal Lipom olgusu literatür eşliğinde sunuldu.Öğe Novel prognostic grayscale ultrasonographic findings in the testis from a comprehensive analysis of pediatric patients with testicular torsion(Elsevier Sci Ltd, 2019) Afşarlar, Çağatay Evrim; Çakmakçı, Emin; Demir, Emre; Güney, Güven; Komut, Erdal; Elizondo, Rodolfo; Koh, Chester J.Introduction Although grayscale and Doppler ultrasound (US) findings of testicular torsion (TT) have previously been described in the literature, other US findings may provide more prognostic information to families. Objective The authors hypothesized that a comprehensive analysis of US findings of TT that focused on time-dependent changes would lead to additional ultrasonographic morphologic findings and clinically relevant prognostic information. Study design The authors reviewed the records of pediatric patients with acute TT from 2010 to 2017. The sizes and parenchymal characteristics of the torsed and contralateral testes on US were analyzed in relation to the time duration from the onset of scrotal pain to the time of surgery (0-6 h, 6-12 h, 12-24 h, 24-48 h, and >48 h), torsion degree, and clinical outcomes of the testes. Results Patient demographics, time intervals, and US measurements of the torsed and contralateral testes showed significant differences with respect to testicular viability (Summary Table). The mean volume ratios of torsed to contralateral testis showed significant differences between the 0-6 h and the 12-24 h time groups as well as the 6-12 h and the 12-24 h time groups (P = 0.003 and P = 0.035, respectively), as well as significant differences between the viable and non-viable testes (P = 0.005). Regarding testicular heterogeneity, two novel grayscale sonographic findings were noted: (1) multiple hypoechoic lines that were termed 'testicular fragmentation' and (2) hyperechoic patches that were termed 'testicular patching'. The presence of these two findings were significantly increased as TT time duration increased (P < 0.001), and these findings were significantly associated with testicular non-viability (P < 0.001). Torsion degree was also noted to be significantly higher in the non-viable testes (P < 0.001). Presence of hydrocele or scrotal edema also showed significant differences between the TT time groups (P < 0.001). Discussion The results of this study demonstrated ultrasonographic findings related to time dependent changes in TT and provided prognostic information regarding testicular viability. Conclusions Specific US grayscale findings in torsed testes (testicular fragmentation and testicular patching) were identified that provide prognostic information regarding time duration of testicular torsion and testicular viability. Testicular fragmentation and testicular patching significantly increased as TT time increased, with increasing risk for testicular nonviability.Öğe Servical Cancer Screening Results of A University Hospital İn Middle Region of Turkey(Lippincott Williams & Wilkins, 2016) Toğrul, Cihan; Görkem, Ümit; Güney, Güven; Yılmaz, Dilek; Nergisli, Cansu Kübra; Güngör, Tayfun[Abstract Not Available]Öğe The Oxidative Stress At Lungs After Menopause And The Antioxidant Effects Of Vitamin D, Fish Oil And Exercise in An Experimental Rat Model(Parlar Scientific Publications (P S P), 2020) Arslan, Sertaç; Arslan, Emine; Güney, Güven; Özcan, Oğuzhan; Demir, Emre; Uyar Hazar, Hale; Demirci, BuketMenopause is the permanent cessation of ovarian follicular activity and the menstrual cycle. There is little physiologic and histologic data concerning the possible effects of menopause on respiratory tract and possible beneficial agents for respiratory tract against the effects of menopause. The rat lungs and trachea have been obtainedfrom young and old rats which were treated with either vitamin D (VitD; 1000IU/kg/week),Fish oil (FO; 0.8 mL/kg/week) or exercise (running 45 minutes/3 times/week) for 12 weeks after one week overiectomy (OVX) followup. Oxidative stress markers found increased at OVX and OVX+E groups. However, oxidative stress marker levels were lower at OVX+E group than OVX group. Vitamin D and fish oil also caused decreased oxidative stress at lung tissue compared to OVX group. OVX group had histological changes such as epithelial desquamation, peribronchial smooth muscle hypertrophy, peribronchial lymphoid follicles, Type 2 pneumocyte hyperplasia; however, none of them was found at exercise group. Ovariectomy caused respiratory system effects in rats. Menopause cause oxidative stress; however, exercise, vitamin D and fish oil have protective effects against oxidative stress at lungs at different quantities. Ovariectomy group has the greatest damage compared to other groups. Exercise is the best protective modality against the effects of menopause at respiratory system.Öğe Two-Year Results of Community-Based Screening Program for Human Papilloma Virus DNA in Çorum Province(2019) Güney, Güven; Arslan, Emine; Baş, Yılmaz; Turgal, EbruObjective: The Turkish Ministry of Health started a community-based screening program using Human Papilloma Virus (HPV) DNA in 2014. In our study, we aimed to investigate the results of this survey in Çorum province between the years of 2016-17 to determine the shortcomings and deficiencies in practice. Material and Method: All of the women between the ages of 30 and 65 years who had undergone High risk HPV DNA screening in Çorum province between 2016 and 2017 were included in the study. High risk HPV types were divided into three categories as type 16, 18 and others. The target group of patients to be screened were compared with the numbers reached in the survey. After colposcopic biopsy, the clinicopathological correlation of the patients who underwent colposcopic biopsy was determined via pathology reports. Results: HPV DNA was detected in 817 women (3.5%). HPV types 16, 18 and others were found to be positive in 216, 32 and 569 individuals, respectively. Cervical biopsy was performed with colposcopy in 212 (26%) women. As the result of colposcopy, LSIL and HSIL were detected in 63 and 56 patients, respectively. 34.5% of patients with the diagnosis of any kind of dysplasia received treatments. Conclusion: It was determined that 44% of HPV DNA-positive patients were not subjected to the appropriate processes according to the national guidelines. This shows that despite the screening, the desired therapeutic effect could not be achieved.Öğe Ultrasonographic findings in the epididymis of pediatric patients with testicular torsion(Elsevier Ltd, 2017) Afşarlar, Çağatay Evrim; Elizondo, Rodolfo A.; Yılmaz, Engin; Çakmakcı, Ertan; Ballow, Daniel J.; Demir, Emre; Güney, Güven; Koh, Chester J.Introduction Although grayscale ultrasound and color Doppler ultrasound characteristics of the torsed testis are well established in the literature, less is known about its anatomic partner: the epididymis. Objective The purpose of this study was to describe the ultrasound characteristics of the epididymis in pediatric patients with testicular torsion, and to describe their potential role as prognostic criteria for testicular salvage outcomes. Study design During a retrospective review of 217 pediatric patients with acute testicular torsion during 2009–2016, morphological features of the epididymis from scrotal ultrasounds (size, parenchymal characteristics, and vascular flow of both epididymis heads), as well as patient demographics, time duration, surgical outcomes, histopathology results, and follow-up periods were analyzed. Results Mean epididymis size and twisting degree were significantly higher in the torsed testes than in the contralateral epididymis (P < 0.001) (Summary table). Cystic structures in the epididymis were identified: a higher number of cysts was associated with testicular non-viability (P = 0.025) and higher twisting degree (P = 0.017). Histopathologic examination showed that these spaces were infiltrated connective tissue most likely formed by venous congestion and vessel rupture. Discussion Scrotal ultrasound can provide information on testicular morphology and viability, as well as morphological changes in the epididymis over time in pediatric patients with testicular torsion. These findings may provide potential prognostic information regarding testicular viability, as a higher number of cystic spaces in the epididymis was associated with a higher rate of testicular non-viability and a higher twisting degree. In addition, the epididymis size (volume) can change during the time course of the ischemic state. Conclusions This was the first study to describe and analyze epididymis ultrasound findings in pediatric patients with testicular torsion and to correlate them with testicular salvage outcomes. Further prospective studies are needed to determine the role of epididymis ultrasound findings as a potential pre-operative prognostic tool.[Table presented] © 2017 Journal of Pediatric Urology Company
