Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurosurgical Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AIM: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI). MATERIAL and METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-?) and interleukin (IL)-1? were measured. RESULTS: The resveratrol group had statistically significant lower levels of TNF-?, IL -1?, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells. CONCLUSION: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects. © 2018 Turkish Neurosurgical Society.
Açıklama
Anahtar Kelimeler
Neuroprotection, Neuroregeneration, Rat, Resveratrol, Spinal Cord Injury, TUNEL
Kaynak
Turkish Neurosurgery
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
28
Sayı
6
Künye
Şentürk, S., Yaman, M. E., Aydın, H. E., Güney, G., Bozkurt, İ., Paksoy, K., Abdioğlu, A. A. (2018). Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury. Turkish Neurosurgery, 28(6), 889-896.
