Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury

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dc.contributor.authorŞentürk, Salim
dc.contributor.authorYaman, Mesut Emre
dc.contributor.authorAydın, Hasan Emre
dc.contributor.authorGüney, Güven
dc.contributor.authorBozkurt, İsmail
dc.contributor.authorPaksoy, Kemal
dc.contributor.authorAbdioğlu, Ahmet Atilla
dc.date.accessioned2019-05-13T08:58:46Z
dc.date.available2019-05-13T08:58:46Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractAIM: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI). MATERIAL and METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-?) and interleukin (IL)-1? were measured. RESULTS: The resveratrol group had statistically significant lower levels of TNF-?, IL -1?, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells. CONCLUSION: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects. © 2018 Turkish Neurosurgical Society.
dc.identifier.citationŞentürk, S., Yaman, M. E., Aydın, H. E., Güney, G., Bozkurt, İ., Paksoy, K., Abdioğlu, A. A. (2018). Effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury. Turkish Neurosurgery, 28(6), 889-896.
dc.identifier.doi10.5137/1019-5149.JTN.21829-17.3
dc.identifier.endpage896en_US
dc.identifier.issn1019-5149
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage889en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.21829-17.3
dc.identifier.urihttps://hdl.handle.net/11491/1195
dc.identifier.volume28en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish Neurosurgical Society
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeuroprotectionen_US
dc.subjectNeuroregenerationen_US
dc.subjectRaten_US
dc.subjectResveratrolen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectTUNELen_US
dc.titleEffects of resveratrol on inflammation and apoptosis after experimental spinal cord injury
dc.typeArticle

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