Synthesis of chitosan-based hydrogels as a novel drug release device for wound healing

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dc.authorid0000-0002-5913-8333
dc.authorid0000-0003-1535-4381
dc.contributor.authorTamahkar Irmak, Emel
dc.contributor.authorĂ–zkahraman, Bengi
dc.date.accessioned2019-06-12T06:38:18Z
dc.date.available2019-06-12T06:38:18Z
dc.date.issued2017en_US
dc.departmentHitit Üniversitesi, Mühendislik Fakültesi, Kimya Mühendisliği Bölümü
dc.descriptionresearch
dc.description.abstractThe development of the porous, biocompatible and biodegradable hydrogels has been gaining much attention for wound dressing applications. The hydrogels prepared using freeze-thawing method present important properties of high biocompatibility and nontoxicity. The hydrogels that are able to release drugs for prolonged time are widely used biomaterials for wound healing. In this study chitosan (CS)-based poly-?-caprolactone (PCL) hydrogels were prepared using poly vinyl alcohol (PVA), poly ethylene glycol (PEG) and poly vinyl pyrrolidone (PVP). PVA-CS-PCL hydrogels only could remain stable at room temperature after synthesis. The properties of the hydrogels were determined with SEM, FTIR, swelling tests and degradation tests. The drugs of ceftazidime (CZ) as an antibiotic and ketoprofen (KP) as an analgesic were loaded onto the hydrogels and the loaded hydrogels were used for the drug release studies at pH 5.5 and pH 7.4. All these results suggest that the developed PVA-CS-PCL hydrogels offer significant potential as a wound dressing material.
dc.identifier.citationTamahkar, E., Ă–zkahraman, B.(2017). Synthesis of chitosan-based hydrogels as a novel drug release device for wound healing. Hittite Journal of Science and Engineering, 4(2),137-144.
dc.identifier.doi10.17350/HJSE19030000060
dc.identifier.endpage144en_US
dc.identifier.issn2149-2123
dc.identifier.issue2en_US
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.17350/HJSE19030000060
dc.identifier.urihttps://hdl.handle.net/11491/3307
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherHitit University
dc.relation.ispartofHittite Journal of Science and Engineering
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChitosan-Based Hydrogelen_US
dc.subjectWound Dressingen_US
dc.subjectDrug Releaseen_US
dc.subjectCeftazidimeen_US
dc.subjectKetoprofenen_US
dc.titleSynthesis of chitosan-based hydrogels as a novel drug release device for wound healing
dc.typeArticle

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