Tourniquet-induced ischaemia-reperfusion injury: the comparison of antioxidative effects of small-dose propofol and ketamine

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dc.authoridAhiskalioglu, Ali / 0000-0002-8467-8171
dc.authoridAhiskalioglu, Ali / 0000-0002-8467-8171
dc.authorwosidAhiskalioglu, Ali / B-7473-2016
dc.authorwosidAhiskalioglu, Ali / K-5343-2019
dc.contributor.authorOmer, Karaca
dc.contributor.authorNermin, Gogus
dc.contributor.authorAli, Ahiskalioglu
dc.contributor.authorMehmet, Aksoy
dc.contributor.authorUnal, Dogus
dc.contributor.authorSezen, Kumas Solak
dc.contributor.authorHakan, Kalafat
dc.date.accessioned2021-11-01T15:01:46Z
dc.date.available2021-11-01T15:01:46Z
dc.date.issued2017
dc.department[Belirlenecek]
dc.description.abstractObjectives: The aim of the present study was to investigate the preventive effects of propofol and ketamine as small dose sedation during spinal anaesthesia on tourniquet-induced ischaemia-reperfusion injury. Methods: 30 patients were randomly assigned into two groups of 15 patients. In the propofol group, sedation was performed with propofol 0.2 mgkg(-1) followed by infusion at a rate of 2 mg.kg(-1).h(-1). In the ketamine group, a continuous infusion of ketamine 0.5 mg.kg(-1)-h(-1) was used until the end of surgery. Intravenous administration of midazolam was not used in any patients. Ramsay sedation scale was used for assessing the sedation level. Venous blood samples were obtained before propofol and ketamine infusion (T1), at 30 minutes (min) of tourniquet ischaemia (T2), and 5 min after tourniquet deflation (T3) for malondialdehyde (MDA) measurements. Results: No differences were noted between the groups in haemodynamic (p > 0.05) and demographic data (p > 0.05). There was no statistically significant difference between the two groups in terms of T1, T2 and T3 periods (p > 0.05). There was a statistically increase observed in MDA values respectively both in Group P and Group K between the reperfusion period (1.95 +/- 0.59, 2.31 +/- 0.48) and pre-ischaemia (1.41 +/- 0.38, 1.54 +/- 0.45), and ischaemia (1.76 +/- 0.70, 1.71 +/- 0.38) (mu moL(-1)) periods (p < 0.05). Conclusions: Small-dose propofol and ketamine has similar potential to reduce the oxidative stress caused by tourniquet-induced ischaemia-reperfusion injury in patients undergoing arthroscopic knee surgery under spinal anaesthesia. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.
dc.identifier.doi10.1016/j.bjane.2015.09.005
dc.identifier.endpage250en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue3en_US
dc.identifier.pmid27842707
dc.identifier.startpage246en_US
dc.identifier.urihttps://doi.org/10.1016/j.bjane.2015.09.005
dc.identifier.urihttps://hdl.handle.net/11491/6651
dc.identifier.volume67en_US
dc.identifier.wosWOS:000401600800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofRevista Brasileira De Anestesiologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPropofolen_US
dc.subjectKetamineen_US
dc.subjectArthroscopic knee surgeryen_US
dc.subjectIschaemia reperfusionen_US
dc.titleTourniquet-induced ischaemia-reperfusion injury: the comparison of antioxidative effects of small-dose propofol and ketamine
dc.typeArticle

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