Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon-Metal Based Composite Sensor

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dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorBaymak Çelik, Melek Şirin
dc.contributor.authorÇelik, Hayati
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T08:58:50Z
dc.date.available2019-05-13T08:58:50Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractDienogest is a synthetic oral progestogen with unique pharmacological properties that is used orally in the treatment of endometrosis. The first time, the detailed electrochemical mechanism of dienogest is investigated in different aqueous mediums. Different progestins were used to understand completely oxidation mechanism. The electrochemical oxidation of dienogest was investigated systematically by cyclic voltammetry, differential pulse voltammetry, and square wave voltammetry. A simple adsorptive stripping square wave voltammetry method has been developed for the fully validated direct determination of dienogest in Visanne Tablets for the first time. Nano based sensor was fabricated with reduced graphene oxide, gold and carboxylic acid functionalized multi-walled carbon nanotube materials, and were used on glassy carbon electrode that performed sensitive and validated analysis of dienogest by adsorptive stripping square wave voltammetry. Validation parameters were investigated in detail. The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00×10?7 M to 6.00×10?6 M, with LOD and LOQ values as 1.88×10?8 M and 6.27×10?8 M, respectively. In the future, the developed sensor can be applied in different media such as environment, soil and water for the detection of some progestins or hormones by researchers. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.identifier.citationBakirhan, N. K., Celik, M. S. B., Celik, H., Uslu, B., & Ozkan, S. A. (2018). Electrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon?Metal Based Composite Sensor. Electroanalysis, 30(10), 2273-2283.
dc.identifier.doi10.1002/elan.201800373
dc.identifier.endpage2283en_US
dc.identifier.issn1040-0397
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage2273en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201800373
dc.identifier.urihttps://hdl.handle.net/11491/1206
dc.identifier.volume30en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDienogesten_US
dc.subjectOxidationen_US
dc.subjectSquare Wave Voltammetryen_US
dc.subjectSurface Modified Electrodeen_US
dc.subjectValidationen_US
dc.titleElectrochemical Approach on Mechanism of an Oral Progestin in Aqueous Media and its Fully Validated Detection via a Carbon-Metal Based Composite Sensor
dc.typeArticle

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