Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells

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dc.authoridAydin, Oktay / 0000-0001-5728-0128
dc.authoridozden, huseyin / 0000-0002-2786-3805
dc.authoridUzun, Hafize / 0000-0002-1347-8498
dc.authoridAydin, Gulcin / 0000-0001-9672-7666
dc.authoridSahiner, Ibrahim Tayfun / 0000-0002-3921-7675
dc.authorwosidAydin, Oktay / H-5912-2018
dc.authorwosidozden, huseyin / AAY-4242-2021
dc.authorwosidUzun, Hafize / D-4811-2019
dc.contributor.authorAydin, Oktay
dc.contributor.authorKaraca, Gokhan
dc.contributor.authorPehlivanli, Faruk
dc.contributor.authorAltunkaya, Canan
dc.contributor.authorUzun, Hafize
dc.contributor.authorOzden, Huseyin
dc.contributor.authorGuler, Osman
dc.date.accessioned2021-11-01T15:01:51Z
dc.date.available2021-11-01T15:01:51Z
dc.date.issued2018
dc.department[Belirlenecek]
dc.description.abstractBackground: The present study investigated the effectiveness of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) in wound healing suppressed by corticosteroid in rats. Methods: Forty rats were separated into four groups. To disrupt the wound-healing processes, intraperitoneal single dose 10 mg/kg methylprednisolone was administered to all rats with the exception of Sham-S group. Then, full-thickness incision was performed to the abdominal skin of all animals, and PRP or MSCs were applied to the incision line except the Sham-S and Sham-M group animals. Ten days later, all animals were sacrificed to investigate: tissue collagenization, inflammation, and re-epithelialization grades histopathologically; and tissue hydroxyproline (HP), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha levels biochemically. Results: Collagenization (p = 0.003) and inflammation grade (p = 0.002) values were higher in PR group. Tissue HP level value was found to be high in MC group (p < 0.001). Tissue IL-1 beta level value of Sham-M group was lower than those of other groups (p < 0.001). Conclusions: This preliminary study revealed that PRP could improve the histopathological grades in wound healing which was suppressed by corticosteroid in rats, while MSCs could show their therapeutic effects via biochemical route. These positive effects were more salient in PR group.
dc.identifier.doi10.3390/jcm7060143
dc.identifier.issn2077-0383
dc.identifier.issue6en_US
dc.identifier.pmid29890683
dc.identifier.urihttps://doi.org/10.3390/jcm7060143
dc.identifier.urihttps://hdl.handle.net/11491/6719
dc.identifier.volume7en_US
dc.identifier.wosWOS:000436276500028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal Of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectplatelet-rich plasmaen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectwound healingen_US
dc.titlePlatelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells
dc.typeArticle

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