Effect of 3-aminobenzamide on perforation an experimental colitis model

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dc.authoridDincel, Aylin Sepici / 0000-0001-5847-0556
dc.authorwosidDincel, Aylin Sepici / N-4321-2019
dc.contributor.authorMenekse, Ebru
dc.contributor.authorAydin, Sezai
dc.contributor.authorDincel, Aylin Sepici
dc.contributor.authorEroglu, Abdullah
dc.contributor.authorDolapci, Mete
dc.contributor.authorYildirim, Osman
dc.contributor.authorCengiz, Omer
dc.date.accessioned2021-11-01T14:58:11Z
dc.date.available2021-11-01T14:58:11Z
dc.date.issued2014
dc.department[Belirlenecek]
dc.description.abstractBackground/Aims: The anti-inflammatory activity of 3-aminobenzamide (3-AB) has been shown via histopathology and immunohistochemistry in various colitis models. We aimed to study the effects of 3-AB on tissue mechanical endurance and, associatively, preventing perforation in colitis. Materials and Methods: Thirty male Wistar albino rats were randomly divided into three groups. Rectal saline was administered to Group 1 (sham + saline). Rectal trinitrobenzensulphonic acid was applied to induce colitis in Group 2 (colitis + saline) and Group 3 (colitis + 3-AB). Groups 1 and 2 were treated intraperitoneally with saline (1 ml every 12 hours) and Group 3 was treated with 3-AB (10 mg/kg every 12 hours). After seven days, rats were sacrificed and colon lipid peroxidation levels, the serum tumor necrosis factor alpha (TNF-alpha) level, bowel bursting pressures, and bowel wall tensions were measured. Results: Bowel bursting pressure in Group 2 was significantly lower than in Groups 1 and 3 (p<0.001 for both groups). Bowel wall tension in Group 2 was significantly lower than in Groups 1 and 3 (p<0.001 for both groups). There were no significant differences between groups for serum TNF-alpha levels. For lipid peroxidation, malondialdehyde (MDA) levels were increased in Groups 2 and 3 compared to Group 1. Conclusion: 3-AB may aid prevention of perforations that develop in inflammatory bowel disease, requiring surgical treatment.
dc.identifier.doi10.5152/tjg.2014.4288
dc.identifier.endpage91en_US
dc.identifier.issn2148-5607
dc.identifier.pmid25910375
dc.identifier.startpage86en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2014.4288
dc.identifier.urihttps://hdl.handle.net/11491/6509
dc.identifier.volume25en_US
dc.identifier.wosWOS:000353553700017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherAves
dc.relation.ispartofTurkish Journal Of Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPoly (ADP-ribose) polymerase/synthetase inhibitoren_US
dc.subject3-aminobenzamideen_US
dc.subjectcolitisen_US
dc.subjectinflammatory bowel diseaseen_US
dc.titleEffect of 3-aminobenzamide on perforation an experimental colitis model
dc.typeArticle

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