Effect of Catalytically Active Zinc Oxide-Carbon Nanotube Composite on Sensitive Assay of Desloratadine Metabolite

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dc.authoridKARADAS BAKIRHAN, NURGUL / 0000-0001-5469-9142
dc.contributor.authorOzturk, Kubra
dc.contributor.authorBakirhan, Nurgul K.
dc.contributor.authorOzkan, Sibel A.
dc.contributor.authorUslu, Bengi
dc.date.accessioned2021-11-01T15:05:02Z
dc.date.available2021-11-01T15:05:02Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractDesloratadine is one of the most effective second-generation antihistamines and the electrochemical behavior of the active agent of desloratadine was investigated with a new nanosensor designed with the addition of zinc oxide and multiwalled carbon nanotube (ZnO : MWCNT) mixture on glassy carbon (GCE). By investigating and using cyclic, differential pulse and square wave voltammetry techniques with ZnO : MWCNT/GCE, it is planned to obtain information about quantification and mechanism of desloratadine. The efficiency of experimental parameters such as pH, scan rate, accumulation potential and time on the anodic response of desloratadine were studied. Differential pulse voltammetry was selected as assay method and under developed method and optimized conditions, the current showed linear dependence with concentration in the range between 2x10(-8) and 8x10(-6) M in pH 5.5 acetate buffer. The achieved limits of detection (LOD) and quantification (LOQ) are 0.769 nM and 2.56 nM respectively. Applicability of the methods was demonstrated by their implementation in pharmaceutical dosage forms of desloratadine and the accuracy, precision, selectivity, sensitivity, intra-day and day-to-day reproducibility of the methods were clearly explored. Finally, this sensor was successfully applied on real sample as a selective, simple, reproducible, repeatable an electrochemical sensor.
dc.description.sponsorshipAnkara University, Department of Scientific Research Project [17L0237001]en_US
dc.description.sponsorshipThe authors acknowledge the financial support of Ankara University, Department of Scientific Research Project (Project Number: 17L0237001). This work was produced from the PhD Dissertation of Kubra Ozturk (Ankara University, Health Sciences Institute).en_US
dc.identifier.doi10.1002/elan.201900193
dc.identifier.endpage58en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85071050895
dc.identifier.scopusqualityQ2
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1002/elan.201900193
dc.identifier.urihttps://hdl.handle.net/11491/7062
dc.identifier.volume32en_US
dc.identifier.wosWOS:000483130300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectrochemistryen_US
dc.subjectNanosensoren_US
dc.subjectPharmaceutical Analysisen_US
dc.subjectDesloratadineen_US
dc.titleEffect of Catalytically Active Zinc Oxide-Carbon Nanotube Composite on Sensitive Assay of Desloratadine Metabolite
dc.typeArticle

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