EFFECTS OF BORIC ACID ON PROINFLAMMATION CYTOKINES, TOTAL OXIDATIVE-ANTIOXIDATIVE STATUS AND HEMATOLOGICAL PARAMETERS IN RATS APPLIED BENZO(a)PYRENE

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dc.authoridComba, Arzu / 0000-0001-9462-8998
dc.authorwosidComba, Arzu / AAI-4424-2021
dc.contributor.authorComba, Arzu
dc.contributor.authorOto, Gokhan
dc.contributor.authorComba, Bahat
dc.contributor.authorOzdemir, Hulya
dc.contributor.authorKeskin, Siddik
dc.contributor.authorAkveran, Gonul Arslan
dc.date.accessioned2021-11-01T15:05:03Z
dc.date.available2021-11-01T15:05:03Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractThe aim of this study was to evaluate effects of boric acid (BA) on tumor necrosis factor-alfa (TNF-alpha), interleukin 1 beta (IL-beta), interleukin-6 (IL-6), total oxidative (TOS)-total anti oxidative status (TAS) and leucocyte (WBC), erythrocyte (RBC), thrombocyte (PLT) and their other parameters in rats applied benzo(a)pyrene (B(a)P). In this study, rats were divided into 4 groups and each group were containing 6 rats. 1st group was separated as control group. 100 mg/kg total dosage of B(a)P was applied to the 2nd group 2 times a week total in 4 equal dosage with i.p. way. Only BA 300 mg/L was applied to 3rd group in drinking water every day during 150 days. B(a)P was applied twice a week first 2 weeks, 25 mg/kg dose with i.p. way and BA were given with drinking water during 150 days to 4th group. In the end of study was determined TNF-alpha and IL-1 beta levels in B(a)P group, increases compared with other groups. there was a statistically significant increase in levels of WBC and LY in group B(a)P+BA compared to other groups (P <= 0.05). % LY level in other groups was higher; its % NEU level was lower according to control group. RBC and PLT values in BA group were higher, than the other groups. HGB was higher in group BA than group B(a)P and BA+ B(a)P; HCT was higher in group BA than group B(a)P , significantly (P <= 0.05) As a result, neutropenia and lenfositos develop in case exposure of B(a)P and BA; furthermore, combination of B(a)P and BA increases WBC. BA used alone having considerable effect on excitation of eritopoezis and thrombocytosis. BA has protective effects for organisms together with decrease in the TNF-alpha and IL-1 beta levels caused by BA cure as solution of B(a)P exposition.
dc.identifier.endpage3605en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85091956358
dc.identifier.scopusqualityN/A
dc.identifier.startpage3599en_US
dc.identifier.urihttps://hdl.handle.net/11491/7069
dc.identifier.volume29en_US
dc.identifier.wosWOS:000535839400031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherParlar Scientific Publications (P S P)
dc.relation.ispartofFresenius Environmental Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectB(a)Pen_US
dc.subjectboric aciden_US
dc.subjectinflammationen_US
dc.subjectinterleukinen_US
dc.subjectneutropeniaen_US
dc.subjectTASen_US
dc.titleEFFECTS OF BORIC ACID ON PROINFLAMMATION CYTOKINES, TOTAL OXIDATIVE-ANTIOXIDATIVE STATUS AND HEMATOLOGICAL PARAMETERS IN RATS APPLIED BENZO(a)PYRENE
dc.typeArticle

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