Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method

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dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T08:59:00Z
dc.date.available2019-05-13T08:59:00Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractRatio derivative spectrophotometric technique is presented for the rapid, accurate and precise simultaneous determination of olmesartan medoxomil (OLM), hydrochlorothiazide (HCT), and zofenopril (ZOF) as well as HCT binary mixtures in their dosage forms. First derivative of the ratio spectra (DD1) by measurements using different amplitudes was used and calibration graphs were established for 0.5–12 mg/mL HCT and 0.5–20 mg/mL OLM and ZOF. This method depends on first derivative of the ratio spectra by division of the absorption spectrum of the binary mixture by a standard spectrum of one of the components and then calculating the first derivative of the ratio spectrum. The first derivative of the ratio amplitudes at 250.4 and 291.5 nm for OLM, 250.4 and 298.1 nm for ZOF and 231.8, 332.2, 232.3 and 280.4 nm for HCT were selected for the determination. The proposed methods were successfully applied for determining of both drug combinations (ZOF-HCT and OLM-HCT) in their synthetic mixtures and in pharmaceutical dosage forms. The described procedures are extensively validated, non-destructive and do not require any separation steps. © 2014, Pleiades Publishing, Ltd.
dc.identifier.citationKurbanoğlu, S., Gümüştaş, M., Özkan, S. A. (2014). Simultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method. Journal of Analytical Chemistry, 69(10), 935-941.
dc.identifier.doi10.1134/S1061934814100116
dc.identifier.endpage941en_US
dc.identifier.issn1061-9348
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage935en_US
dc.identifier.urihttps://doi.org/10.1134/S1061934814100116
dc.identifier.urihttps://hdl.handle.net/11491/1236
dc.identifier.volume69en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaik Nauka Publishing / Springer SBM
dc.relation.ispartofJournal of Analytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrochlorothiazideen_US
dc.subjectOlmesartanen_US
dc.subjectRatio Derivative Spectrophotometryen_US
dc.subjectZofenoprilen_US
dc.titleSimultaneous determination and validation of some binary mixtures of antihypertensive drugs using ratio derivative spectrophotometric method
dc.typeArticle

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