Expression of pSTAT3 and TNF-? in normotensive and severe preeclamptic placentas

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dc.contributor.authorToğrul, Cihan
dc.contributor.authorGörkem, Ümit
dc.contributor.authorİrtegün, Sevgi
dc.contributor.authorTahaoğlu, Ali Emre
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorDeveci, Engin
dc.date.accessioned2019-05-13T09:08:08Z
dc.date.available2019-05-13T09:08:08Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: To examine histopathologic changes and correlation between TNF-? and pSTAT3 expression levels by western blot and immunohistochemical methods in preeclamptic placentas. STUDY DESIGN: Obstetrical properties and biochemical and hematological features of patients with preeclampsia and healthy subjects were compared. Paraffin sections obtained from placenta were stained with hematoxylin-eosin for histopathologic examination. RESULTS: In histopathologic examination of preeclamptic placentas, cytotrophoblastic cellular proliferation, fibrinoid necrosis, endothelial proliferation, and calcified and hyalinized villous spots were observed. CONCLUSION: In preeclamptic placentas, we observed that trophoblastic invasion may downregulate STAT3 phosphorylation and can correlate with TNF-? elevation. Even though trophoblast invasion may interfere with both vascular and immune systems, TNF-? is not directly involved in the STAT3 signaling pathway in the preeclamptic placenta. © Science Printers and Publishers, Inc.
dc.identifier.citationToğrul, C., Görkem, Ü., İrtegün, S., Tahaoğlu, A. E., Güngör, T., Deveci, E. (2017). Expression of pSTAT3 and TNF-? in normotensive and severe preeclamptic placentas. Analytical and Quantitative Cytopathology and Histopathology, 39(3), 149-156.
dc.identifier.endpage156en_US
dc.identifier.issn0301-102X
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage149en_US
dc.identifier.urihttps://hdl.handle.net/11491/1942
dc.identifier.volume39en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScience Printers and Publishers Inc.
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPlacentaen_US
dc.subjectPreeclampsiaen_US
dc.subjectSTAT3en_US
dc.subjectTNF-αen_US
dc.titleExpression of pSTAT3 and TNF-? in normotensive and severe preeclamptic placentas
dc.typeArticle

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