Antimicrobial and cytotoxic evaluation of new quinazoline derivatives

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dc.authorid0000-0003-3667-5846
dc.contributor.authorTuran Zitouni, Gülhan
dc.contributor.authorYurttasş, Leyla
dc.contributor.authorSaka, Güner
dc.contributor.authorCantürk, Zerrin
dc.contributor.authorKaraca Gençer, Hülya
dc.contributor.authorBaysal, Merve
dc.contributor.authorKaplancıklı, Zafer Asım
dc.date.accessioned2019-05-13T09:08:50Z
dc.date.available2019-05-13T09:08:50Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe synthesis of nine new quinazoline derivatives (2a-2i) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine was used as the initial starting material. The intermediate product, 2-hydrazinyl-6,7- dimethoxyquinazolin-4-amine, was reacted with appropriate aromatic aldehydes to obtain 2-(2-benzylidenehydrazinyl)-6,7-dimethoxyquinazolin-4-amine derivatives as final compounds. The structures of the compounds were elucidated by 1H- and 13C-NMR, IR, and MS analyses. The new pure compounds were evaluated for their potential antimicrobial and cytotoxic activities using in vitro microdilution and cell culture techniques, respectively. The compounds 2e and 2f may be promising candidates for the treatment of fungal infections with their activity and cytotoxicity.
dc.identifier.citationTuran Zitouni, G., Yurttaş, L., Saka, G., Cantürk, Z., Gencer, H. K., Baysal, M., Kaplanc?kl?, Z. A. (2016). Antimicrobial and cytotoxic evaluation of new quinazoline derivatives. Natural Product Communications, 11(11), 1645-1648.
dc.identifier.endpage1648en_US
dc.identifier.issn1934-578X
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage1645en_US
dc.identifier.urihttps://hdl.handle.net/11491/2060
dc.identifier.volume11en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNatural Product Incorporation
dc.relation.ispartofNatural Product Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimicrobial Activityen_US
dc.subjectCytotoxicityen_US
dc.subjectHydrazoneen_US
dc.subjectQuinazolineen_US
dc.titleAntimicrobial and cytotoxic evaluation of new quinazoline derivatives
dc.typeArticle

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