Butyrylcholinesterase as an additional marker in the diagnostic network of acute myocardial infarction

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dc.authoridErdemli, Hacı Kemal / 0000-0002-3399-4676
dc.authorwosidKocabaş, Ramazan / M-2512-2016
dc.authorwosidErenler, Ali Kemal / AAA-2995-2020
dc.contributor.authorKocabaş, Ramazan
dc.contributor.authorErenler, Ali Kemal
dc.contributor.authorYetim, Mücahit
dc.contributor.authorDoğan, Tolga
dc.contributor.authorErdemli, Hacı Kemal
dc.date.accessioned2021-11-01T14:58:17Z
dc.date.available2021-11-01T14:58:17Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Acute coronary syndrome defines a broad spectrum of complaints from angina to irreversible myocardial damage. There is an ongoing need for a biomarker to predict and diagnose acute myocardial infarction (AMI) in the early stage. In this study, our aim was to reveal early diagnostic value of butyrylcholinesterase (BChE) in discrimination of healthy subjects and patients with AMI. Methods: Eighty-five patients admitted to our hospital due to AMI and 45 healthy subjects were involved in the study. Patients and controls were compared according to BChE, lipid profiles and biochemical parameters. Results: The serum BChE activity was significantly lower in patients with AMI than in the controls (p < 0.001). After correlation analysis, while a negative correlation was determined between the serum BChE concentrations and AMI presence (r = -0.363, p < 0.001); a positive correlation was determined between the serum BChE and cholesterol (r = 0.443, p < 0.001), HDL (r = 0.243, p = 0.006) and LDL (r = 0.369, p < 0.001) levels. The data indicate that BChE is associated with AMI and a subsequent receiver operating characteristic curve (ROC) analysis revealed that BChE, as an independent indicator, may differentiate AMI patients from controls. A cut-off point set at = 7.15 kIU/L, BChE showed a sensitivity of 51.2% and a specificity of 84.4% (AUC = 0.719, p < 0.001). Conclusions: Low BChE level was significantly associated with AMI when compared to healthy subjects. Even though it has low sensitivity, plasma levels of BChE might represent an additional marker in the diagnostic network of AMI.
dc.identifier.citationKocabaş, R., Erenler, A. K., Yetim, M., Doğan, T., & Erdemli, H. K. (2016). Butyrylcholinesterase as an additional marker in the diagnostic network of acute myocardial infarction. LaboratoriumsMedizin, 40(2), 147-152.
dc.identifier.doi10.1515/labmed-2015-0086
dc.identifier.endpage152en_US
dc.identifier.issn0342-3026
dc.identifier.issn1439-0477
dc.identifier.issue2en_US
dc.identifier.startpage147en_US
dc.identifier.urihttps://doi.org/10.1515/labmed-2015-0086
dc.identifier.urihttps://hdl.handle.net/11491/6571
dc.identifier.volume40en_US
dc.identifier.wosWOS:000374097400009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorErdemli, Hacı Kemal
dc.institutionauthorKocabaş, Ramazan
dc.institutionauthorErenler, Ali Kemal
dc.institutionauthorYetim, Mücahit
dc.institutionauthorDoğan, Tolga
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofLaboratoriumsmedizin-Journal Of Laboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectBiomarkeren_US
dc.subjectButyrylcholinesteraseen_US
dc.titleButyrylcholinesterase as an additional marker in the diagnostic network of acute myocardial infarction
dc.typeArticle

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