Effects of recurrent sevofl urane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease

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dc.contributor.authorDuruk Erkent, Fatmanur
dc.contributor.authorIşık, Berrin
dc.contributor.authorKüçük, Ayşegül
dc.contributor.authorÖztürk, Levent
dc.contributor.authorNeşelio?lu, Salim
dc.contributor.authorTatlı Doğan, Hayriye
dc.contributor.authorGüney, S.
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2020-01-22T07:03:44Z
dc.date.available2020-01-22T07:03:44Z
dc.date.issued2019en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: We aimed to investigate the effects of recurrent sevofl urane anesthesia on cognitive functions in Alzheimer Disease. MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevofl urane (Group S), Alzheimer’s (Group A) and Alzheimer’s + sevofl urane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 ?l) STZ. Sevofl urane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed. RESULTS: In RAM test, the entry-exit data were signifi cantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were signifi cantly decreased in Group S. Glial-fi brillaryacidic protein levels were signifi cantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfi de levels were found to be signifi cantly different in the A and AS groups. CONCLUSION: Sevofl urane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51)
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dc.identifier.citationErkent, F. D., Isık, B., Küçükk, A., ÖztÜrk, L., Neşelioğlu, S., Doğan, H. T., ... & Arslan, M. (2019). Effects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease. Bratislavske lekarske listy, 120(12), 887-893.
dc.identifier.doi10.4149/BLL_2019_149
dc.identifier.endpage893en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage887en_US
dc.identifier.urihttps://hdl.handle.net/11491/5656
dc.identifier.volume120en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofBratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimeren_US
dc.subjectSevofl Uraneen_US
dc.subjectRadial Arm Maze Testen_US
dc.subjectRaten_US
dc.subjectGFAPen_US
dc.subjectCaspase-3en_US
dc.titleEffects of recurrent sevofl urane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease
dc.typeArticle

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