Diagnostic impacts of serum Ca-125 levels, pap smear evaluation, and endometrial sampling in women with endometrial clear cell carcinoma

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dc.contributor.authorÇetinkaya, Nilüfer
dc.contributor.authorSelçuk, İlker
dc.contributor.authorÖzdal, Bülent
dc.contributor.authorMeydanlı, Mehmet Mutlu
dc.contributor.authorGüngör, Tayfun
dc.date.accessioned2019-05-13T09:07:52Z
dc.date.available2019-05-13T09:07:52Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground: Endometrial clear cell carcinoma (ECCC) is a rare variant of endometrial cancer with an unfavorable prognosis. The aim of this study was to determine the relationships, if any, between preoperative serum cancer antigen 125 (CA-125) levels, the last Papanicolaou (Pap) smear, the results of endometrial biopsy and tumor histology, and disease-stage according to permanent histopathology. Materials and Methods: The data of 26 women with ECCC were collected from their medical records to compare demographics, preoperative serum CA-125 levels, Pap test results, histological diagnosis of the endometrial biopsy, and tumor histology, as well as the disease stage according to permanent histopathology. Results: The mean age at diagnosis was 64.0 years. There were 17 (65.3%) women with pure ECCC and 8 (30.7%) women with a mixed histology. Stage III-IV disease was diagnosed in 12 (46.2%) women and occurred more frequently in pure ECCC (n = 11, 91.7%). CA-125 values were significantly higher in advanced stage disease. Cytological evaluation indicated the presence of 71.4% (10/14) cytological abnormalities in pure ECCC. The overall sensitivity of endometrial sampling for the detection of malignancy was 92.3% (24/26), whereas the accurate diagnosis of ECCC was only 34.7% (8/23) with the Pipelle sampler. Conclusion: Pap test abnormalities are frequent in ECCC. Although it is less accurate in the diagnosis of ECCC than in the detection of malignancy, endometrial sampling is still the main procedure for the diagnosis of ECCC. Higher preoperative CA-125 concentrations imply the presence of advanced stage ECCC. © 2016 S. Karger GmbH, Freiburg.
dc.identifier.citationÇetinkaya, N., Selcuk, İ., Özdal, B., Meydanlı, M. M., Güngör, T. (2016). Diagnostic impacts of serum CA-125 levels, pap smear evaluation, and endometrial sampling in women with endometrial clear cell carcinoma. Oncology Research and Treatment, 39(5), 283-288.
dc.identifier.doi10.1159/000445860
dc.identifier.endpage288en_US
dc.identifier.issn2296-5270
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.1159/000445860
dc.identifier.urihttps://hdl.handle.net/11491/1890
dc.identifier.volume39en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherS. Karger AG
dc.relation.ispartofOncology Research and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCA-125en_US
dc.subjectClear Cell Carcinomaen_US
dc.subjectEndometrial Samplingen_US
dc.subjectPapanicolaou Smearen_US
dc.titleDiagnostic impacts of serum Ca-125 levels, pap smear evaluation, and endometrial sampling in women with endometrial clear cell carcinoma
dc.typeArticle

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