Factors associated with increased irisin levels in the type 1 diabetes mellitus

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dc.contributor.authorAteş, İhsan
dc.contributor.authorArıkan, Mehmet Fettah
dc.contributor.authorErdoğan, Kübra
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorYüksel, Mahmut
dc.contributor.authorTopçuoğlu, Canan
dc.contributor.authorYılmaz, Nisbet
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:02:38Z
dc.date.available2019-05-13T09:02:38Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective. The aim of the present study was to determine the irisin levels in patients with the type 1 diabetes mellitus (T1DM) and to examine the relation of irisin levels with the inflammation and autoimmunity. Methods. This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Antiglutamic acid decarboxylase (anti-GAD), islet cell antibody (ICA), and insulin autoantibody levels were measured in patients at the time when they were included into the study and recorded from the patient files. Serum irisin levels were measured by ELISA kit. Results. The median irisin levels were determined higher in T1DM group compared to the control one (6.8 ng/ml vs. 4.8 ng/ml, p=0.022; respectively). Median irisin levels were higher in anti-GAD (p=0.022) and ICA (p=0.044) positive groups compared to negative groups. In T1DM group, irisin levels displayed positive correlation with glycosylated hemoglobin (HbA1c) (r=0.377, p<0.001) and anti-GAD (r=0.392, p=0.020) and negative correlation with creatinine (r=-0390, p=0.021). In multivariate regression model, HbA1c (B±SE: 2.76±17683, p<0.001), and anti-GAD (B±SE: 2.311±0.610, p=0.001) were determined as independent predictors for predicting the irisin levels. Conclusion. In patients with T1DM, which chronic inflammation and autoimmunity take part in their etiopathogenesis, anti-GAD levels were an independent risk factor for the irisin. This may suggest that factors such as inflammation and autoimmunity can be effective in the synthesis of irisin. © 2017, De Gruyter Open Ltd. All rights reserved.
dc.identifier.citationAteş, İ., Arıkan, M. F., Erdoğan, K., Kaplan, M., Yüksel, M., Topçuoğlu, C., Yılmaz, N., Güler, S. (2017). Factors associated with increased irisin levels in the type 1 diabetes mellitus. Endocrine Regulations, 51(1), 1-7.
dc.identifier.doi10.1515/enr-2017-0001
dc.identifier.endpage7en_US
dc.identifier.issn1210-0668
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1515/enr-2017-0001
dc.identifier.urihttps://hdl.handle.net/11491/1294
dc.identifier.volume51en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherDe Gruyter Open Ltd
dc.relation.ispartofEndocrine Regulations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 2.0 Generic (CC BY 2.0)*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/*
dc.subjectPGC1-αen_US
dc.subjectFibronectin Type III Domain Containing 5en_US
dc.subjectHbA1cen_US
dc.subjectHyperglycemiaen_US
dc.subjectIAnti-Glutamic Acid Decarboxylaseen_US
dc.titleFactors associated with increased irisin levels in the type 1 diabetes mellitus
dc.typeArticle

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