Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats

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dc.authoridEkinci, Adnan / 0000-0001-7725-8024
dc.authoridKesici, Hakan / 0000-0001-8013-3302
dc.authorwosidEkinci, Adnan / AAD-5731-2020
dc.contributor.authorEkinci, Adnan
dc.contributor.authorKoç, Sema
dc.contributor.authorErdoğan, Ahmet Serhat
dc.contributor.authorKesici, Hakan
dc.date.accessioned2021-11-01T15:01:50Z
dc.date.available2021-11-01T15:01:50Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjectives: We aimed to investigate the prophylactic effect simvastatin of and mitomycin C (MMC) on laryngeal and tracheal stenosis in tracheotomised rats by histopathological evaluation of laryngotracheal segment. Randomized prospective single-blind. Material and method: Standard vertical tracheotomy was performed on 24 rats. Then the animals were randomly divided into three groups as A, B and C. In group A 0.4 mg/day once daily mitomycin C was injected to the paratracheal region for 14 days. In group B daily 30 mg/kg/day simvastatin was given via gavage to rats for 14 days. In group C 2 cc/day intraperitoneal saline given to rats and the created control group by 14 days follow up. After 10 days, tracheal cannulas were removed. Three weeks later, all animals were euthanized and trachea specimens were harvested. The present study investigates the effects of MMC and Simvastatin on fibrosis, inflammation, stenosis index and tracheal wall thickness in a tracheal injury model. Results: The difference between the groups in terms of degree of inflammation scores was statistically insignificant (P = 0,187). Differences between the groups were found to be insignificant in terms of the preventionof fibrosis (P = 0,993). There was no significant difference between groups in terms of stenosis index (P = 0.645). In terms of wall thickness, control, simvastatin and mitomycin C groups were statistically different (p = 0.038). The difference between post-hoc test results was between Mitomycin C and control groups (p = 0.036). Maximum wall thickness in the MMC group (0,299 mm) was significantly lower compared to the control group (0,382 mm)(P < 0,0001). Maximum wall thickness was statistically lower in the simvastatin (0.324 mm) group compared with the control group (0.382 mm) (P < 0.0001). There was no statistically significant difference between the simvastatin group (0,198 mm) and control group (0,200 mm) with respect to minimum wall thickness (P = 0.982). Minimum wall thickness was significantly lower in the mitomycin-C group (0,160 mm) comparison to the control group (0,200 mm) (P < 0.0001). Conclusion: It was detected that the simvastatin and MMC is not effective in preventing the tracheal stenosis, inflammation and fibrosis formation.
dc.identifier.citationEkinci, A., Koc, S., Erdoğan, A. S., & Kesici, H. (2018). Profilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats. International Journal of Pediatric Otorhinolaryngology, 105, 79-84.
dc.identifier.doi10.1016/j.ijporl.2017.10.001
dc.identifier.endpage84en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid29447825
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2017.10.001
dc.identifier.urihttps://hdl.handle.net/11491/6708
dc.identifier.volume105en_US
dc.identifier.wosWOS:000426234500017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorEkinci, Adnan
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTracheal stenosisen_US
dc.subjectMitomycin-Cen_US
dc.subjectSimvastatinen_US
dc.subjectFibrosisen_US
dc.subjectInflammationen_US
dc.titleProfilactic role of simvastatin and mitomycin C in tracheal stenosis after tracheal damage: Study in rats
dc.typeArticle

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