The redox mechanism investigation of non-small cell lung cancer drug: Erlotinib via theoretical and experimental techniques and its host–guest detection by ?-Cyclodextrin nanoparticles modified glassy carbon electrode
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Erlotinib (ERL) is a tyrosine kinase inhibitor which prevents growing of cancer cells. The electrochemical oxidation mechanism of ERL was studied in details using cyclic voltammetry. Cyclic voltammetry, differential pulse and square wave voltammetric techniques were applied for sensitive, fast, precise determination of ERL. Adsorptive stripping square wave voltammetry was selected and applied to the assay of ERL in pharmaceutical dosage forms. Quantitative application and its validation were realized via ?-Cyclodextrin nanoparticles modified glassy carbon electrode in 0.1 M phosphate buffer pH 3.0 in the presence of 20% methanol. The adsorptive stripping square wave voltammetry provided linear response within the concentration ranges 1.00 × 10?8 M - 8.00 × 10-6 M (r = 0.999) with LOD and LOQ values 1.07 × 10-9 M and 3.58 × 10-9 M, respectively. The recovery of erlotinib in Tarceva® tablets was 100.38%. In addition, computational studies were exerted to complement to the analytical studies, The molecular electrostatic potential surface and frontier molecular orbitals have been calculated at the DFT level and on B3LYP/6?31+G* to elucidate the ERL oxidation behavior. The results shown that the theoretical data were consistent with the proposed oxidation mechanism of ERL. © 2018 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Adsorptive Stripping Square Wave Voltammetry, Anticancer Drug, Computational Analysis, Electronic Properties, Erlotinib, β-Cyclodextrin
Kaynak
Sensors and Actuators, B: Chemical
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
278
Sayı
Künye
Bakırhan, N. K., Tok, T. T., Özkan, S. A. (2019). The redox mechanism investigation of non-small cell lung cancer drug: Erlotinib via theoretical and experimental techniques and its host–guest detection by ?-Cyclodextrin nanoparticles modified glassy carbon electrode. Sensors and Actuators B: Chemical, 278, 172-180.
