Inherited risk factors in low-risk venous thromboembolism in patients under 45 years

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dc.contributor.authorYilmaz, Seyhan
dc.contributor.authorGunaydin, Serdar
dc.date.accessioned2021-11-01T14:58:15Z
dc.date.available2021-11-01T14:58:15Z
dc.date.issued2015
dc.department[Belirlenecek]
dc.description.abstractOBJECTIVES: Venous thromboembolism (VTE) is a complex disease and an important preventable cause of morbidity and mortality today. Many genetic and acquired factors contribute to its aetiology. The aim of the present study is to investigate the incidence of inherited risk factors for thrombophilia in patients under 45 years of age who presented with VTE without having a major acquired risk factor. METHODS: Of 96 VTE patients who presented to our outpatient department between February 2012 and November 2013, 58 were considered eligible for the study. Blood samples taken for thrombophilia testing were investigated in a molecular genetics and diagnosis laboratory. These data were collected prospectively and analysed retrospectively. RESULTS: The mean age of patients in our study was 39.12 +/- 2.1 years. Of the 58 patients, 30 had factor V Leiden mutation (5 homozygous, 25 heterozygous), 16 had prothrombin gene mutation, 24 had methylenetetrahydrofolate reductase C677T mutation (5 homozygous, 19 heterozygous), 18 had protein C deficiency, 17 had protein S deficiency, 14 had antithrombin III deficiency and 13 had hyperhomocysteinaemia. We observed that at least one inherited risk factor was present in most of the patients with VTE (n = 45), a finding that was compatible with those of previous studies. CONCLUSIONS: Inherited risk factors are common among patients who present with VTE but have no major acquired risk factors. We conclude that these patients should be further evaluated for evidence of molecular risk factors.
dc.identifier.doi10.1093/icvts/ivu346
dc.identifier.endpage23en_US
dc.identifier.issn1569-9293
dc.identifier.issn1569-9285
dc.identifier.issue1en_US
dc.identifier.pmid25326427
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1093/icvts/ivu346
dc.identifier.urihttps://hdl.handle.net/11491/6549
dc.identifier.volume20en_US
dc.identifier.wosWOS:000350198300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofInteractive Cardiovascular And Thoracic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVenous thromboembolismen_US
dc.subjectGeneticen_US
dc.subjectThrombophiliaen_US
dc.titleInherited risk factors in low-risk venous thromboembolism in patients under 45 years
dc.typeArticle

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