Is The Preoperative C-Reactive Protein/Albumin Ratio Successful in Predicting Postoperative Pancreatic Fistula in Patients Undergoing Pancreatoduodenectomy? A Case-control Study
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Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CAROL DAVILA UNIV MEDICINE & PHARMACY PUBL
Erişim Hakkı
Özet
Pancreaticoduodenectomy (PD) is a complex procedure with a high complication rate. Postoperative pancreatic fistula (POPF) is a major complication. Therefore, preoperative determination of POPF risk is clinically important. The C-reactive protein-albumin ratio (CAR) is a parameter used for prognosis in some types of cancer. We hypothesized that CAR could serve as a predictive parameter of POPF. In this study, we investigated whether CAR can predict the risk of POPF after PD in patients with pancreatic cancer. Methods: A total of 83 patients were included in this study between March 2017 and December 2023. This retrospective evaluation included demographic characteristics, preoperative laboratory findings, preoperative clinic and hospital records, and the surgical and treatment conditions of patients undergoing PD for pancreatic cancer in our department. Results: POPF was observed in 41 patients. CAR value was significantly elevated in the POPF group (P< 0.001). According to the Receiver Operating Characteristic (ROC) analysis results, the optimal cut-off point determined for CAR was 0.445. Univariate and Multivariate Binary Logistic Regression analyses showed that CAR was reliable for predicting POPF (odds 57.2). Conclusion: Preoperative CAR is a reliable predictive marker for POPF following PD.
Açıklama
Anahtar Kelimeler
C-reactive protein, albumin, postoperative pancreatic fistula
Kaynak
ROM J MIL MED
WoS Q Değeri
Scopus Q Değeri
Cilt
128
Sayı
2
