Is The Preoperative C-Reactive Protein/Albumin Ratio Successful in Predicting Postoperative Pancreatic Fistula in Patients Undergoing Pancreatoduodenectomy? A Case-control Study

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dc.contributor.authorKartal, B
dc.contributor.authorAkdoğan, MY
dc.contributor.authorTurhan, VB
dc.contributor.authorŞahiner, İT
dc.contributor.authorAlkurt, EG
dc.date.accessioned2026-03-31T13:21:12Z
dc.date.available2026-03-31T13:21:12Z
dc.date.issued2025
dc.description.abstractPancreaticoduodenectomy (PD) is a complex procedure with a high complication rate. Postoperative pancreatic fistula (POPF) is a major complication. Therefore, preoperative determination of POPF risk is clinically important. The C-reactive protein-albumin ratio (CAR) is a parameter used for prognosis in some types of cancer. We hypothesized that CAR could serve as a predictive parameter of POPF. In this study, we investigated whether CAR can predict the risk of POPF after PD in patients with pancreatic cancer. Methods: A total of 83 patients were included in this study between March 2017 and December 2023. This retrospective evaluation included demographic characteristics, preoperative laboratory findings, preoperative clinic and hospital records, and the surgical and treatment conditions of patients undergoing PD for pancreatic cancer in our department. Results: POPF was observed in 41 patients. CAR value was significantly elevated in the POPF group (P< 0.001). According to the Receiver Operating Characteristic (ROC) analysis results, the optimal cut-off point determined for CAR was 0.445. Univariate and Multivariate Binary Logistic Regression analyses showed that CAR was reliable for predicting POPF (odds 57.2). Conclusion: Preoperative CAR is a reliable predictive marker for POPF following PD.
dc.identifier.doi10.55453/rjmm.2025.128.2.1
dc.identifier.issn1222-5126
dc.identifier.issn2501-2312
dc.identifier.issue2
dc.identifier.urihttp://dx.doi.org/10.55453/rjmm.2025.128.2.1
dc.identifier.urihttps://hdl.handle.net/11491/9595
dc.identifier.volume128
dc.identifier.wosWOS:001460393000001
dc.language.isoen
dc.publisherCAROL DAVILA UNIV MEDICINE & PHARMACY PUBL
dc.relation.ispartofROM J MIL MED
dc.subjectC-reactive protein
dc.subjectalbumin
dc.subjectpostoperative pancreatic fistula
dc.titleIs The Preoperative C-Reactive Protein/Albumin Ratio Successful in Predicting Postoperative Pancreatic Fistula in Patients Undergoing Pancreatoduodenectomy? A Case-control Study
dc.typeArticle

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