Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization

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dc.contributor.authorHasçiçek, Canan
dc.contributor.authorŞengel Türk, Ceyda Tuba
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.contributor.authorBakar, Filiz
dc.contributor.authorDaş Evcimen, Net
dc.contributor.authorSavaşer, Ayhan
dc.contributor.authorÖzkan, Yalçın
dc.date.accessioned2019-05-13T09:07:07Z
dc.date.available2019-05-13T09:07:07Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe present investigation was aimed at optimizing Fulvestrant (FLV)-loaded nanoparticulate formulations to overcome side effects caused by the intramuscular injection of FLV, and to prolong local intratumoral action at high drug concentration. Novel poly(ethylene glycol) (PEG) conjugated poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PEG-b-PLGA), and poly(ethylene glycol)-block-poly(?-caprolactone) (PEG-b-PCL) nanoparticles were used as the drug-loading vehicles. The influence of hydrophobicity of the two different polymeric materials based nanoparticles was investigated with respect to in vitro properties, cytotoxic capacity and cell uptake potency. The sphere-shaped nanoparticles ranged between 84.56 and 220.20 nm, had negative surface charges, and exhibited sustained release profiles. In-vitro cytotoxicity results demonstrated that nanoparticles prepared with the higher hydrophilic form of PEG-b-PCL, a diblock copolymer composition, exerted the highest inhibitory effect on the proliferation of MCF-7 cells and significantly increased the intracellular uptake, compared to free FLV and the other tested polymer-based formulations. The final data of this research indicated that polymer hydrophobicity was a key to improving the major characteristics, especially anti-proliferative activity of the developed polymer-based nanoparticles. The drug delivery systems formulated here are promising nanocarriers for FLV delivery and have potential for the treatment of hormone-dependent breast cancers. © 2017 Elsevier B.V.
dc.identifier.citationHasçiçek, C., Şengel Türk, C. T., Gümüştas, M., Özkan, A. S., Bakar, F., Daş Evcimen, N., Savaşer, A., Özkan, Y. (2017). Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization. Journal of Drug Delivery Science and Technology, 40, 73-82.
dc.identifier.doi10.1016/j.jddst.2017.06.001
dc.identifier.endpage82en_US
dc.identifier.issn1773-2247
dc.identifier.scopusqualityQ1
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2017.06.001
dc.identifier.urihttps://hdl.handle.net/11491/1728
dc.identifier.volume40en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditions de Sante
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Canceren_US
dc.subjectFulvestranten_US
dc.subjectMCF-7en_US
dc.subjectPEG-B-PCLen_US
dc.subjectPEG-B-PLGAen_US
dc.subjectPolymer-Based Nanoparticlesen_US
dc.titleFulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization
dc.typeArticle

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