Selective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods

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dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorCoşkun, Gökçe
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:15Z
dc.date.available2019-05-10T09:39:15Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractDetailed electrochemical study and novel voltammetric and LC methods are presented for the determination of repaglinide (RPG) in pharmaceuticals. Repaglinide in methanol: buffer solution (20:80; v/v) shows one or two anodic responses on glassy carbon electrode between pH 0.3 and 12.0 depending on the pH values. The HPLC and UPLC methods were developed using core shell columns with mobile phase consisting of 50:50; ACN:Water (0.05 % TFA; at pH: 3.0) (v/v) with UV detection at 215 nm. Finally, the proposed methods were successfully applied for the determination of RPG in pharmaceutical dosage forms. The proposed voltammetric and LC methods allow a number of cost and time saving benefits. RPG was also exposed to thermal, photolytic, oxidative stress, acid-base catalyzed hydrolyses, and the stressed samples were detected by the proposed RP-HPLC method.
dc.identifier.citationGumustas, M., Coskun, G., & Ozkan, S. A. (2015). Selective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods. Revue Roumaine de Chimie, 60(5), 477-490.
dc.identifier.endpage490en_US
dc.identifier.issn0035-3930
dc.identifier.issue05.Junen_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage477en_US
dc.identifier.urihttps://hdl.handle.net/11491/647
dc.identifier.volume60en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditions de l'Academie Republique Populaire
dc.relation.ispartofRevue Roumaine de Chimie
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleSelective and sensitive determination of repaglinide in pharmaceuticals by voltammetric and LC methods
dc.typeConference Object

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