In vitro CNS models

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dc.authorid0000-0002-0347-0222
dc.contributor.authorKara, Aslı
dc.contributor.authorÖztürk, Naile
dc.contributor.authorVural, İmran
dc.contributor.editorGürsoy Özdemir, Yasemin
dc.contributor.editorŞekerdağ, Emine
dc.date.accessioned2019-05-13T09:09:07Z
dc.date.available2019-05-13T09:09:07Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Sungurlu Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractEndothelial cells form a barrier between the blood and the central nervous system, namely the blood-brain barrier (BBB). Cellular components of the BBB, as well as tight junctions and paracellular barrier characterizations, are described in this chapter. Furthermore, in vitro BBB models are classified as 2D models (monoculture and coculture), 3D, dynamic, and microfluidic models and further explained in detail. The components of the neurovascular unit and their role in obtaining special BBB properties in vitro are outlined, and methods that mimic the dynamic nature of an in vivo microenvironment are discussed. Promising approaches, such as stem cells and microfluidics, for future modeling of the BBB are also mentioned throughout this chapter. As a result it has been concluded that for drug discovery and delivery studies, which target the central nervous system, in vitro BBB models are very useful. © 2017 Elsevier Inc. All rights reserved.
dc.identifier.citationKara, A., Öztürk, N., Vural, İ. (2017). In vitro CNS models. Y. Gürsoy Özdemir and E. Şekerdağ (Eds.), Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier (pp. 151-185). England: Academic Press
dc.identifier.doi10.1016/B978-0-12-803796-6.00008-3
dc.identifier.endpage185en_US
dc.identifier.isbn9780128038000; 9780128037966
dc.identifier.scopusqualityN/A
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-803796-6.00008-3
dc.identifier.urihttps://hdl.handle.net/11491/2106
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofNanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCodynamic Modelsen_US
dc.subjectIn Vitro BBB Modelsen_US
dc.subjectMicrofluidicsen_US
dc.subjectStem Cellsen_US
dc.titleIn vitro CNS models
dc.typeBook Part

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