Ameliorative effects of Hesperidin on radiation induced brain injury in rats

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dc.authorwosidCAN, Murat / S-6630-2016
dc.contributor.authorKale, A.
dc.contributor.authorPiskin, O.
dc.contributor.authorBas, Y.
dc.contributor.authorAydin, B. G.
dc.contributor.authorCan, M.
dc.contributor.authorElmas, O.
dc.contributor.authorBuyukuysal, C.
dc.date.accessioned2021-11-01T15:01:59Z
dc.date.available2021-11-01T15:01:59Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractBackground: Extensive research has been focused on radiation induced brain injury. Animal and human studies have shown that flavonoids have remarkable toxicological profiles. This study aims to investigate the neuroprotective effects of hesperidin in an experimental radiation induced brain injury. Materials and Methods: 32 adult male Wistar-Albino rats were randomly divided into 4 groups (control, hesperidin, radiation, and radiation+hesperidin groups; 8 rats in each group). 200 mg/kg doses of hesperidin were administered to the animals in the hesperidin and radiation+ hesperidin groups, radiation and radiation+ hesperidin groups were exposed to a dose of 20 Gy cranium region. Tissue samples, and biochemical levels of tissue injury markers in four groups were compared. Results: In all measured parameters of oxidative stress, administration of hesperidin significantly demonstrated favorable effects. Both plasma and tissue levels of malondialdehyde and total antioxidant status significantly changed in favor of antioxidant activity. Histopathological evaluation of the tissues also demonstrated significant decrease in cellular degeneration and infiltration parameters after hesperidin administration. Conclusion: This Hesperidin demonstrated significant neuroprotection after radiation induced brain injury. Further studies with different experimental settings including neurological outcome are required to achieve conclusive results.
dc.identifier.doi10.18869/acadpub.ijrr.17.2.229
dc.identifier.endpage236en_US
dc.identifier.issn2322-3243
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85072246841
dc.identifier.scopusqualityQ4
dc.identifier.startpage229en_US
dc.identifier.urihttps://doi.org/10.18869/acadpub.ijrr.17.2.229
dc.identifier.urihttps://hdl.handle.net/11491/6791
dc.identifier.volume17en_US
dc.identifier.wosWOS:000469966100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherIjrr-Iranian Journal Radiation Res
dc.relation.ispartofInternational Journal Of Radiation Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRadiationen_US
dc.subjectbrain injuryen_US
dc.subjecthesperidinen_US
dc.subjectneuroprotectionen_US
dc.titleAmeliorative effects of Hesperidin on radiation induced brain injury in rats
dc.typeArticle

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