Evaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism

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dc.contributor.authorTuna, Mazhar Müslüm
dc.contributor.authorAyçiçek Doğan, Berçem
dc.contributor.authorKarakılıç, Ersen
dc.contributor.authorArduç, Ayşe
dc.contributor.authorIşık, Serhat
dc.contributor.authorYılmaz, Fatma Meriç
dc.contributor.authorTopçuoğlu, Canan
dc.contributor.authorBerker, Dilek
dc.contributor.authorGüler, Serdar
dc.date.accessioned2019-05-13T09:08:06Z
dc.date.available2019-05-13T09:08:06Z
dc.date.issued2014
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: Hypogonadism has major effects on the urogenital system, in addition to other systems, the cardiovascular system in particular. There have been few studies conducted on markers of atherosclerosis, such as flow mediated dilatation (% FMD), carotid intima-media thickness (CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal (IHH) males mostly in adult patients. The aim of this study was to evaluate the relationship between androgens and adipocytokines and parameters of vascular functions in hypogonadal men. j MATERIALS AND METHODS: The study population consisted of 11 treatment naive IHH patients (group 1) and 15 age-matched healthy control males (group 2). A fasting blood sample was obtained for leptin, adiponectin and resistin. The endothelial functions were evaluated by studying % FMD and CIMT by high resolution B-mode ultrasound. RESULTS: No significant differences in age, body mass index, systolic and diastolic blood pressure were recorded between the two groups. The leptin level was significantly higher in group 1, whereas adiponectin and resistin levels were same between two groups. There was a negative correlation between total testosterone and carotid intima-media thickness (r=-0.656, p=0.008), and a negative correlation between total testosterone and leptin level (r=-0.794, p<0.001). No correlation was found between leptin and CIMT (p=0.184). CONCLUSION: Testosterone deficiency in hypogonadal men is associated with vascular parameters of atherosclerosis. The findings may establish indications for testosterone replacement therapy in hypogonadal men. © 2014 Neuroendocrinology Letters.
dc.identifier.citationTuna, M. M., Ayçiçek Doğan, B., Karakılıç, E., Arduç, A., Işık, S., Yılmaz, F. M., Topçuoğlu, C., Berker, D.[et.al.]. (2014). Evaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism. Neuroendocrinology Letters, 35(7), 640-644.
dc.identifier.endpage644en_US
dc.identifier.issn0172-780X
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage640en_US
dc.identifier.urihttps://hdl.handle.net/11491/1938
dc.identifier.volume35en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMaghira and Maas Publications
dc.relation.ispartofNeuroendocrinology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdipocytokineen_US
dc.subjectHypogonadotrophic Hypogonadismen_US
dc.subjectVascular Functionsen_US
dc.titleEvaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism
dc.typeArticle

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