The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy

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dc.authorid0000-0003-2893-692X
dc.authorid0000-0003-2319-0807
dc.authorwosidHPD-5211-2023
dc.contributor.authorŞahin, Tayfun
dc.contributor.authorKarabulut, Alpaslan
dc.date.accessioned2023-11-22T08:09:42Z
dc.date.available2023-11-22T08:09:42Z
dc.date.issued2023en_US
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjectives Diabetic retinopathy (DRP) is one of the most common microvascular complications of diabetes. The pigment epithelium-derived factor (PEDF) is a protein that is one of the most potent angiogenesis inhibitors. The effect of blood PEDF concentration on DRP formation remains unclear. The present study aimed to determine whether the plasma concentration of PEDF is effective on the appearance of DRP. Methods The present study consisted of 62 patients with diabetes mellitus and 20 healthy participants. The patient group included 28 patients with non-proliferative DRP, 13 with proliferative DRP, and 21 diabetic patients without DRP. The PEDF levels in patient serum samples were detected through the ELISA method. The body mass index of the participants was calculated. Results Serum PEDF levels of diabetic patients (1.533 ± 0.233??g/mL) were found to be lower (2.163 ± 0.343??g/mL) than healthy participants (p=0.002). The PEDF levels were similar in the DRP and non-DRP groups (p=0.337). The plasma PEDF level decreased along with the progression of DRP (p=0.001). Conclusions The PEDF concentration in the blood decreases along with the increase of DRP grade. Decreased blood concentration of PEDF may be important to predict microvascular complications. Agents containing PEDF may be used intraocularly/systemically for therapeutic purposes to prevent vascular complications of diabetes in the near future.
dc.description.provenanceSubmitted by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2023-11-22T08:08:49Z No. of bitstreams: 0en
dc.description.provenanceApproved for entry into archive by Zeynep Umut NARİN (umutarslan@hitit.edu.tr) on 2023-11-22T08:09:42Z (GMT) No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2023-11-22T08:09:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2023en
dc.identifier.citationŞahin, T., & Karabulut, A. (2023). The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy. Turkish Journal of Biochemistry, 48(5), 525-530.
dc.identifier.doi10.1515/tjb-2023-0078
dc.identifier.endpage530en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue5en_US
dc.identifier.startpage525en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0078
dc.identifier.urihttps://hdl.handle.net/11491/8698
dc.identifier.volume48en_US
dc.identifier.wosWOS:001061741900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahin, Tayfun
dc.institutionauthorKarabulut, Alpaslan
dc.language.isoen
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetic retinopathyen_US
dc.subjectPigment epitheliumderived factoren_US
dc.subjectDiabetic complicationsen_US
dc.subjectDiabetes mellitusen_US
dc.titleThe association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy
dc.typeArticle

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