Turning toxic cigarette butt waste into the sensor material for the sensitive determination of antihypertensive drug trandolapril from its dosage form and biological samples

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dc.authorwosidBilge, Selva / AAT-4838-2020
dc.contributor.authorBilge, Selva
dc.contributor.authorBakirhan, Nurgul K.
dc.contributor.authorDonar, Yusuf Osman
dc.contributor.authorSinag, Ali
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2021-11-01T15:02:02Z
dc.date.available2021-11-01T15:02:02Z
dc.date.issued2019
dc.department[Belirlenecek]
dc.description.abstractThe findings of this study revealed that hydrothermal carbonization (HTC) of filter parts of smoked cigarette butts generates carbonaceous materials that have porosity and high surface area (1012 m(2) g(-1)). This method is relatively eco-friendly because it performed in closed system and under mild conditions. In this study, porous carbon obtained from HTC of smoked cigarette filters was applied in an electroanalytical drug analysis. The surface morphology and chemical structure of the as-prepared materials were illuminated using with different techniques. The voltammetric behavior of antihypertensive drug trandolapril (TRD) was investigated on glassy carbon electrode (GCE) that modified by cigarette filter derived char/Nitrogen doped carbon spheres (c-char/NCS). The electrooxidation of TRD was demonstrated a diffusion-controlled fashion at pH 3.0 phosphate buffer (PB) solution. The calibration curve was linear between 8 x 10(-8) and 8 x 10(-5) M. The detection limit (LOD) was obtained as 1.09 x 10(-10) M in pH 3.0 PB solution and 2.57 x 10(-8) M in human serum samples by DPV. We try to show that the novel electrochemical sensor was easily applied for the determination of TRD using various carbon structures produced from urea and filter parts of cigarette butts.
dc.description.sponsorshipScientific Research Projects Coordination Unit (BAP) of Ankara University, TurkeyAnkara University [18B0430007]; Higher Education Council of Turkey (YOK)Ministry of National Education - Turkeyen_US
dc.description.sponsorshipThe authors offer their gratitude to Scientific Research Projects Coordination Unit (BAP) of Ankara University, Turkey for provide financial support within the Project 18B0430007. Higher Education Council of Turkey (YOK) was greatly appreciated for providing scholarship to Selva Bilge. The authors are also grateful to Prof. Dr. Zeki Aktas for BET analysis. In addition, the authors thank the pharmaceutical company ABBOTT for the materials.en_US
dc.identifier.doi10.1016/j.snb.2019.126626
dc.identifier.issn0925-4005
dc.identifier.scopus2-s2.0-85066404395
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.snb.2019.126626
dc.identifier.urihttps://hdl.handle.net/11491/6815
dc.identifier.volume296en_US
dc.identifier.wosWOS:000475314800090
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofSensors And Actuators B-Chemical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSensoren_US
dc.subjectCigarette buttsen_US
dc.subjectHydrothermal carbonizationen_US
dc.subjectElectrooxidationen_US
dc.subjectTrandolaprilen_US
dc.subjectCarbon spheresen_US
dc.titleTurning toxic cigarette butt waste into the sensor material for the sensitive determination of antihypertensive drug trandolapril from its dosage form and biological samples
dc.typeArticle

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