Kisspeptin and hematologic parameters as predictive biomarkers for first-trimester abortions

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dc.authorscopusid55511868300
dc.authorscopusid56410743500
dc.authorscopusid55667069300
dc.authorscopusid57194348670
dc.authorscopusid25621426500
dc.contributor.authorGörkem, Ümit
dc.contributor.authorKan, Özgür
dc.contributor.authorBostancı, Mehmet Ömer
dc.contributor.authorTaşkıran, Deniz
dc.contributor.authorİnal, Hasan Ali
dc.date.accessioned2021-11-01T14:51:35Z
dc.date.available2021-11-01T14:51:35Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: Spontaneous abortion is the most common complication of early pregnancy, affecting up to 20% of recognized pregnancies. Kisspeptin is predominantly released by placental syncytiotrophoblasts, and regulates their placental invasion into the uterine matrices. We aimed to establish an association of serum kisspeptin levels with pregnancy outcomes during the early gestational stage of the first trimester. Method: In this prospective study, 90 pregnant women in their 7 to 8 6/7 gestational weeks were classified into three groups: (i) The control group, consisting of healthy pregnant women (n=30), (ii) the threatened abortion group (n=30), and (iii) the spontaneous abortion group (n=30). The maternal serum samples were analyzed for complete blood count parameters and kisspeptin levels. Results: There was no statistical difference regarding body mass index (BMI) and gestational age (p=0.370). Regarding detailed obstetric notations, including gravida, parity, abortion, and living children, socioeconomic levels, and employment rates, all study groups were comparable (p>0.05, for all). No significant association was found regarding the biochemical parameters of complete blood count, including neutrophil, lymphocyte, and platelet concentrations, as well as neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratios (PLR) (p>0.05, for all). The median serum kisspeptin levels of the study groups did not differ between the groups (p=0.153). Correlation analysis revealed no significant relationship between serum kisspeptin levels and other study parameters in any study groups (p>0.05, for all) Conclusions: We found no statistically significant relationship between serum kisspeptin concentrations and pregnancy outcomes in the early gestational stage of the first trimester, and serum kisspeptin concentrations did not seem to be a reliable marker to distinguish abortion status from viable pregnancy. © Istanbul Medeniyet University Faculty of Medicine.
dc.identifier.citationGorkem, U., Kan, O., Bostanci, M. O., Taskiran, D., & Inal, H. A. (2021). Kisspeptin and hematologic parameters as predictive biomarkers for first-trimester abortions. Medeniyet Medical Journal, 36(2), 98.
dc.identifier.doi10.5222/MMJ.2021.32549
dc.identifier.endpage105en_US
dc.identifier.issn2149-2042
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85109320524
dc.identifier.scopusqualityQ2
dc.identifier.startpage98en_US
dc.identifier.urihttps://doi.org/10.5222/MMJ.2021.32549
dc.identifier.urihttps://hdl.handle.net/11491/6197
dc.identifier.volume36en_US
dc.indekslendigikaynakScopus
dc.institutionauthorGörkem, Ümit
dc.institutionauthorKan, Özgür
dc.institutionauthorBostancı, Mehmet Ömer
dc.institutionauthorTaşkıran, Deniz
dc.institutionauthorİnal, Hasan Ali
dc.language.isoen
dc.publisherLogos Medical Publishing
dc.relation.ispartofMedeniyet Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbortionen_US
dc.subjectKisspeptinen_US
dc.subjectNeutrophil-to-lymphocyte ratioen_US
dc.subjectPlatelet-to-lymphocyte ratioen_US
dc.titleKisspeptin and hematologic parameters as predictive biomarkers for first-trimester abortions
dc.typeArticle

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