Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status

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dc.contributor.authorYıldırım, Engin
dc.contributor.authorDerici, Mehmet Kürşat
dc.contributor.authorŞimşek, Ömer Yavuz
dc.contributor.authorDemir, Emre
dc.date.accessioned2021-11-01T18:18:06Z
dc.date.available2021-11-01T18:18:06Z
dc.date.issued2019
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractAim: Endometrial polyps are frequently associated with abnormal uterine bleeding. The kispeptin family is one of the peptides that play a role in reproductive functions and whose expression varies in various uterine pathologies. The aim of the study was to determine the relationship between serum Kisspeptin levels and endometrial polyps in women with premenopausal status. Material and Methods: The blood was collected prior to endometrial sampling from women admitted to the hospital due to abnormal uterine bleeding. According to the pathology results, patients were identified as polyp group (n=38) (endometrial polyps) and control group (n=50) (normal endometrial findings). Kisspeptin-54 levels were determined by ELISA method from serum obtained from venous blood. Results: There were no difference was found between the patients’ age, body mass index, gravida, para, abortus and the number of living children were compared (p>0.05). There was no statistically significant difference between the groups in terms of follicle stimulating hormone, luteinizing hormone and thyroid stimulating hormone values (p>0.05). Plasma kisspeptin (1.84±0.93 ng/dL and 1.32±0.47 ng/dL, p= 0.008) and estradiol (90.34±13.02 pg/mL and 81.75±12.36 pg/mL, p=0.002) levels were significantly higher in the polyp group than in the control group. After the Receiver Operating Characteristic (ROC) analysis the area under the curve (AUC) was 1.26 (p= 0.08), (95% CI, 0.550-0.782). The sensitivity value was 0.684 (0.512-0.819), the specificity was 0.620 (0.471- 0.750). Conclusion: The serum Kisspeptin-54 and estradiol levels were found higher in patients with endometrial polyps.
dc.identifier.citationYildirim, E., Derici, M. K., Simsek, O. Y., & Demir, E. (2019). Is there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status. Annals of Medical Research, 26(7), 1253-1257.
dc.identifier.doi10.5455/annalsmedres.2019.04.216
dc.identifier.endpage1257en_US
dc.identifier.issn2636-7688
dc.identifier.issn2636-7688
dc.identifier.issue7en_US
dc.identifier.startpage1253en_US
dc.identifier.urihttps://doi.org10.5455/annalsmedres.2019.04.216
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFM01ERXlNZz09
dc.identifier.urihttps://hdl.handle.net/11491/7900
dc.identifier.volume26en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYıldırım, Engin
dc.institutionauthorDemir, Emre
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAbnormal Uterine Bleedingen_US
dc.subjectEndometrial Polypsen_US
dc.subjectKisspeptinen_US
dc.titleIs there a relationship between serum kisspeptin levels and endometrial polyps in women with premenopausal status
dc.typeArticle

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