eNOS and VEGF Variants Might Increase the Risk of Pancreatic Cancer

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dc.authoridGumusay, Ozge / 0000-0002-6236-9829
dc.authorwosidGumusay, Ozge / AAT-3435-2021
dc.contributor.authorHasan Dagmura
dc.contributor.authorYigit, Serbulent
dc.contributor.authorGumusay, Ozge
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorDaldal, Emin
dc.contributor.authorKarakus, Nevin
dc.date.accessioned2021-11-01T15:05:46Z
dc.date.available2021-11-01T15:05:46Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractBackground: Endothelial nitric oxide synthase (eNOS) is essential in chronic inflammation and carcinogenesis. The association between variants in vascular endothelial growth factor (VEGF) and several cancers still remains uncertain. We studied whether there is a relation between eNOS/VEGF variants and risk of pancreatic cancer (PC). Materials and Methods: This prospective case-control study included 76 PC patients (28 women and 48 men) and 100 healthy controls. Blood samples from all participants were genotyped for eNOS variable number tandem repeat (VNTR) and VEGF insertion/deletion (I/D) variants by PCR. Results: There was a significant difference between groups for the eNOS intron 4 VNTR genotype distributions (p = 0.01). eNOS 4a/4b and 4b/4b genotypes were higher in patients with PC group compared to controls while eNOS 4a/4b genotype was more prevalent in control group than in patient group. Significant differences were observed between groups for the VEGF I/D variant genotype and allele frequencies (p < 0.00, and p < 0.00). VEGF I/D variant I/I genotype and I allele increased in patient group than controls. A statistically significant association was observed when the patients were compared with the controls according to D/D + D/I versus D/D (p < 0.00, OR: 0.094, 95% CI: 0.03-0.22). Conclusions: We provided evidence that eNOS VNTR and VEGF I/D variants might influence the development of PC.
dc.identifier.doi10.3103/S0095452721020031
dc.identifier.endpage182en_US
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85104532165
dc.identifier.scopusqualityQ3
dc.identifier.startpage177en_US
dc.identifier.urihttps://doi.org/10.3103/S0095452721020031
dc.identifier.urihttps://hdl.handle.net/11491/7399
dc.identifier.volume55en_US
dc.identifier.wosWOS:000641257000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofCytology And Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpancreatic canceren_US
dc.subjecteNOSen_US
dc.subjectVEGFen_US
dc.subjectvarianten_US
dc.titleeNOS and VEGF Variants Might Increase the Risk of Pancreatic Cancer
dc.typeArticle

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