Synthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenes

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dc.authoridKIVRAK, Arif / 0000-0003-4770-2686
dc.authoridYILMAZ, Can / 0000-0002-0028-6614
dc.authorwosidKIVRAK, Arif / W-2196-2017
dc.authorwosidKIVRAK, Arif / AAQ-8432-2021
dc.contributor.authorKavak, E.
dc.contributor.authorAlgso, M. A. S.
dc.contributor.authorKonus, M.
dc.contributor.authorYilmaz, C.
dc.contributor.authorLazoglu, A.
dc.contributor.authorKaraagac, S. U.
dc.contributor.authorKivrak, A.
dc.date.accessioned2021-11-01T15:06:00Z
dc.date.available2021-11-01T15:06:00Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstract2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z042]; Van Yuzuncu Yil UniversityYuzuncu Yil University [FYL-2016-5243, FYL-2018-7439]; COST Action Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery [CM1407]; COST Action New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors [CA17104]en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Research Council of Turkey (project no. 114Z042) for providing microwave reactor and chemicals and Van Yuzuncu Yil University (FYL-2016-5243; synthesis of compounds; FYL-2018-7439, financial support). A. Kivrak, C. Yilmaz, and M. Konus would like to acknowledge networking contribution by the COST Action CM1407 Challenging Organic Syntheses Inspired by Nature from Natural Products Chemistry to Drug Discovery. A. Kivrak also would like to acknowledge networking contribution by the COST Action CA17104 New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumors.en_US
dc.identifier.doi10.1134/S1070428021010139
dc.identifier.endpage99en_US
dc.identifier.issn1070-4280
dc.identifier.issn1608-3393
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85101779491
dc.identifier.scopusqualityQ4
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.1134/S1070428021010139
dc.identifier.urihttps://hdl.handle.net/11491/7464
dc.identifier.volume57en_US
dc.identifier.wosWOS:000621823200013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofRussian Journal Of Organic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectthiopheneen_US
dc.subjectcoupling reactionsen_US
dc.subjectheteroaromatic compoundsen_US
dc.subjectADMEen_US
dc.subjectantioxidantsen_US
dc.titleSynthesis, Optimization, ADME Analysis, and Antioxidant Activity of 2-(Arylethynyl)-3-ethynylthiophenes
dc.typeArticle

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