Electrochemical approach for the sensitive determination of anticancer drug epirubicin in pharmaceuticals in the presence of anionic surfactant

Basit Öğe Kaydı
dc.authorid0000-0002-7079-7604
dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorBozal Palabıyık, Burçin
dc.contributor.authorKurbanoğlu, Sevinç
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-10T09:39:15Z
dc.date.available2019-05-10T09:39:15Z
dc.date.issued2013
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this research, sensitive, rapid, different electrochemical methods were developed for the determination of anticancer drug epirubicin. The aim of the study was to fully validated determination of epirubicin in pharmaceuticals, by means of electroanalytical methods. The detailed electrooxidative behavior of epirubicin was investigated using cyclic, differential pulse and square wave voltammetry at boron-doped diamond electrode. The possible oxidation mechanism was discussed. Surfactant effect was also examined using 1×10-3 M sodium dodecyl sulphate. The oxidation process was found nearly irreversible over the pH range studied and exhibited diffusion controlled electrode process. All experimental parameters have been optimized and the following studies were realized under the optimum conditions. The sensor used in this research is suitable for the analysis of the trace amounts of epirubicin in pharmaceuticals. The proposed methods were applied to commercial preparations and average percentage recovery was in good agreement between each other (differential pulse and square wave voltammetry).
dc.identifier.citationBozal-Palabiyik, B., Kurbanoglu, S., Gumustas, M., Uslu, B., & Ozkan, S. A. (2013). Electrochemical approach for the sensitive determination of anticancer drug epirubicin in pharmaceuticals in the presence of anionic surfactant. Rev. Roum. Chim, 58(7-8), 647-658.
dc.identifier.endpage658en_US
dc.identifier.issn0035-3930
dc.identifier.issue07.Augen_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage647en_US
dc.identifier.urihttps://hdl.handle.net/11491/649
dc.identifier.volume58en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditions de l'Academie Republique Populaire
dc.relation.ispartofRevue Roumaine de Chimie
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleElectrochemical approach for the sensitive determination of anticancer drug epirubicin in pharmaceuticals in the presence of anionic surfactant
dc.typeConference Object

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Bildiri Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu