Voltammetric behavior and determination of antidepressant drug paroxetine at carbon-based electrodes

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dc.contributor.authorBrycht, Mariola
dc.contributor.authorSkrzypek, Slawomira
dc.contributor.authorKaradaş Bakırhan, Nurgül
dc.contributor.authorSmarzewska, Sylwia
dc.contributor.authorBozal Palabıyık, Burçin
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.contributor.authorUslu, Bengi
dc.date.accessioned2019-05-13T08:58:15Z
dc.date.available2019-05-13T08:58:15Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractSimple, rapid, sensitive, and reproducible methods were developed for the assay of paroxetine in tablets. The electrooxidative behavior and determination of paroxetine on boron-doped diamond and edge plane graphite electrodes were investigated as details using cyclic, differential pulse, and square wave voltammetric methods. The oxidation process was irreversible and exhibited mixed diffusion-adsorption controlled process depending on pH. The dependence of the peak current and peak potentials on pH, nature of the buffer, and scan rate studies were examined as details. The linear responses have been obtained in the range from 7.0 × 10?7 M to 3.5 × 10?6 M with 6.95 × 10?9 M detection limit for the boron-doped diamond electrode and from 1.0 × 10?8 M to 5.0 × 10?6 M with 1.03 × 10?9 M detection limit for the edge plane graphite electrode. The possible electrooxidation mechanism of paroxetine was investigated by means of model compounds of tamsulosin and mebeverine. It can be suggested that alkoxybenzene moiety may be the responsible group for the oxidation of paroxetine (PRX). The developed methods have been successfully applied for the determination of paroxetine in pharmaceutical dosage form. © 2015, Springer-Verlag Berlin Heidelberg.
dc.identifier.citationBrycht, M., Skrzypek, S., Karadaş Bakırhan, N., Smarzewska, S., Bozal Palabıyık, B., Özkan, S. A., Uslu, B. (2015). Voltammetric behavior and determination of antidepressant drug paroxetine at carbon-based electrodes. Ionics, 21(8), 2345-2354.
dc.identifier.doi10.1007/s11581-015-1390-6
dc.identifier.endpage2354en_US
dc.identifier.issn0947-7047
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage2345en_US
dc.identifier.urihttps://doi.org/10.1007/s11581-015-1390-6
dc.identifier.urihttps://hdl.handle.net/11491/1101
dc.identifier.volume21en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherInstitute for Ionics
dc.relation.ispartofIonics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBoron-Doped Diamond Electrodeen_US
dc.subjectDeterminationen_US
dc.subjectEdge Plane Graphite Electrodeen_US
dc.subjectParoxetineen_US
dc.subjectPharmaceuticalsen_US
dc.subjectVoltammetryen_US
dc.titleVoltammetric behavior and determination of antidepressant drug paroxetine at carbon-based electrodes
dc.typeArticle

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