Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques

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dc.authorid0000-0003-2793-7154
dc.authorid0000-0001-7494-3077
dc.contributor.authorŞengel Türk, Ceyda Tuba
dc.contributor.authorGümüştaş, Mehmet
dc.contributor.authorUslu, Bengi
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2019-05-13T09:09:08Z
dc.date.available2019-05-13T09:09:08Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractCancer is the primary leading cause of mortality in the world. The key of a successful cancer treatment depends on many important parameters, such as the application route, anticancer compound, and dosage form. Among the administration routes, oral application is the most widely used application method. However, oral administration of many molecules as conventional dosage forms is limited due to a major problem-low bioavailability. Nanoscale drug delivery systems can ensure oral administration and improve the oral bioavailability of the drugs. Determination of the chemotherapeutically active molecules from the developed nanoscale systems has an important role in the effectiveness of the nanoparticles. Chromatographic techniques, especially liquid chromatography, are very suitable and accurate ways to determine the content of a pharmaceutical ingredient and its stability in both in vitro and in vivo systems. This chapter describes the importance of lipid- and polymer-based nanoscale drug delivery technologies of the anticancer molecules and summarizes the effect and type of the nanostructures, characterization parameters, analysis parameters, such as column types and mobile phase compositions, and validation parameters. © 2017 Elsevier Inc. All rights reserved.
dc.identifier.citationSengel-Turk, C. T., Gumustas, M., Uslu, B., & Ozkan, S. A. (2017). Nanosized drug carriers for oral delivery of anticancer compounds and the importance of the chromatographic techniques. In Nano-and Microscale Drug Delivery Systems (pp. 165-195). Elsevier.
dc.identifier.doi10.1016/B978-0-323-52727-9.00010-8
dc.identifier.endpage195en_US
dc.identifier.isbn9780323527279; 9780323527286
dc.identifier.scopusqualityN/A
dc.identifier.startpage165en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-323-52727-9.00010-8
dc.identifier.urihttps://hdl.handle.net/11491/2108
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofNano- and Microscale Drug Delivery Systems: Design and Fabrication
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnalytical Characterizationen_US
dc.subjectCanceren_US
dc.subjectDeterminationen_US
dc.subjectDrug Deliveryen_US
dc.subjectOral Applicationen_US
dc.subjectPolymer- and Lipid-Based Nanoparticlesen_US
dc.subjectChromatographyen_US
dc.titleNanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques
dc.typeBook Part

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