Does diurnal variation affect the first trimester fetal aneuploidy screening test biochemical parameters of fetuses with normal nuchal translucency?

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dc.contributor.authorKarslı, Mehmet Fatih
dc.contributor.authorÇakmak, Bülent
dc.contributor.authorSeçkin, Kerem Doğa
dc.contributor.authorAkkaş Yılmaz, Elif
dc.contributor.authorAkgül, Gürcan
dc.contributor.authorToğrul, Cihan
dc.contributor.authorKüçüközkan, Tuncay
dc.date.accessioned2019-05-13T09:04:02Z
dc.date.available2019-05-13T09:04:02Z
dc.date.issued2016
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractObjective: The purpose of this study was to investigate the effect of diurnal variation on biochemical results of first trimester aneuploidy screening test. Methods: A total of 2725 singleton pregnant female, who had normal fetal nuchal translucency (NT) thickness, were included in the study during this period. Individuals were divided into two groups according to the sampling time (morning group: 09:00-11:00 am and afternoon group: 02:00-04:00 pm). Hormonal parameters (free-beta human chorionic gonadotropin [free ?-hCG] and pregnancy-associated plasma protein-A [PAPP-A] multiples of median [MoM] levels) of first trimester (11+0-13+6 weeks) combined aneuploidy screening test were compared between morning and afternoon groups. Results: PAPP-A MoM levels were significantly lower in the afternoon group when compared to the morning group (p = 0.001), whereas free ?-hCG MoM levels were similar in the both groups (p = 0.392). Rate of high risk for Down syndrome (Combine risk >1/300) and amniocentesis ratio were found higher in the afternoon group than morning group, but there were no difference between groups for the number of fetuses with Down syndrome. Conclusion: Receiving the venous blood sample for first trimester aneuploidy screening test in the afternoon causes low PAPP-A MoM levels. © 2015 Taylor & Francis.
dc.identifier.citationKarslı, M. F.,Çakmak, B., Seçkin, K. D., Akkaş Yılmaz, E., Akgül, G., Toğrul, C., Küçüközkan, T. (2016). Does diurnal variation affect the first trimester fetal aneuploidy screening test biochemical parameters of fetuses with normal nuchal translucency?. The Journal of Maternal-Fetal & Neonatal Medicine, 29(11), 1808-1811.
dc.identifier.doi10.3109/14767058.2015.1064105
dc.identifier.endpage1811en_US
dc.identifier.issn1476-7058
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1808en_US
dc.identifier.urihttps://doi.org/10.3109/14767058.2015.1064105
dc.identifier.urihttps://hdl.handle.net/11491/1577
dc.identifier.volume29en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBlood Sampling Timeen_US
dc.subjectDiurnalen_US
dc.subjectFirst Trimester Combined Aneuploidy Screening Testen_US
dc.subjectFree-βhcgen_US
dc.subjectPAPP-Aen_US
dc.titleDoes diurnal variation affect the first trimester fetal aneuploidy screening test biochemical parameters of fetuses with normal nuchal translucency?
dc.typeArticle

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