Randomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: Protocol mf07-01

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dc.contributor.authorSoran, Atilla
dc.contributor.authorÖzmen, Vahit
dc.contributor.authorÖzbaş, Serdar
dc.contributor.authorKaranlık, Hasan
dc.contributor.authorMüslümanoğlu, Mahmut
dc.contributor.authorİğci, Abdullah
dc.contributor.authorCantürk, Zafer
dc.contributor.authorUtkan, Zafer
dc.contributor.authorÖzaslan, Cihangir
dc.contributor.authorEvrensel, Türkan
dc.contributor.authorUras, Cihan
dc.contributor.authorAksaz, Erol
dc.contributor.authorSoyder, Aykut
dc.contributor.authorUğurlu, Ümit
dc.contributor.authorÇöl, Cavit
dc.contributor.authorCabioğlu, Neslihan
dc.contributor.authorBozkurt, Betül
dc.contributor.authorUzunköy, Ali
dc.contributor.authorKöksal, Neşet
dc.contributor.authorGüllüoğlu, Bahadır M.
dc.contributor.authorÜnal, Bülent
dc.contributor.authorAtalay, Can
dc.contributor.authorYıldırım, Emin
dc.contributor.authorErdem, Ergun
dc.contributor.authorSalimoğlu, Semra
dc.contributor.authorSezer, Atakan
dc.contributor.authorKoyuncu, Ayhan
dc.contributor.authorGürleyik, Günay
dc.contributor.authorAlagol, Haluk
dc.contributor.authorUlufi, Nalan
dc.contributor.authorBerberoğlu, Uğur
dc.contributor.authorDülger, Mustafa
dc.contributor.authorCengiz, Ömer
dc.contributor.authorSezgin, Efe
dc.contributor.authorJohnson, Ronald
dc.date.accessioned2019-05-13T08:59:05Z
dc.date.available2019-05-13T08:59:05Z
dc.date.issued2018
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBackground: The MF07-01 trial is a multicenter, phase III, randomized, controlled study comparing locoregional treatment (LRT) followed by systemic therapy (ST) with ST alone for treatment-naïve stage IV breast cancer (BC) patients. Methods: At initial diagnosis, patients were randomized 1:1 to either the LRT or ST group. All the patients were given ST either immediately after randomization or after surgical resection of the intact primary tumor. Results: The trial enrolled 274 patients: 138 in the LRT group and 136 in the ST group. Hazard of death was 34% lower in the LRT group than in the ST group (hazard ratio [HR], 0.66; 95% confidence interval [CI], 0.49–0.88; p = 0.005). Unplanned subgroup analyses showed that the risk of death was statistically lower in the LRT group than in the ST group with respect to estrogen receptor (ER)/progesterone receptor (PR)(+) (HR 0.64; 95% CI 0.46–0.91; p = 0.01), human epidermal growth factor 2 (HER2)/neu(–) (HR 0.64; 95% CI 0.45–0.91; p = 0.01), patients younger than 55 years (HR 0.57; 95% CI 0.38–0.86; p = 0.007), and patients with solitary bone-only metastases (HR 0.47; 95% CI 0.23–0.98; p = 0.04). Conclusion: In the current trial, improvement in 36-month survival was not observed with upfront surgery for stage IV breast cancer patients. However, a longer follow-up study (median, 40 months) showed statistically significant improvement in median survival. When locoregional treatment in de novo stage IV BC is discussed with the patient as an option, practitioners must consider age, performance status, comorbidities, tumor type, and metastatic disease burden. © 2018, Society of Surgical Oncology.
dc.identifier.citationSoran, A., Özmen, V., Özbaş, S., Karanlık, H., Müslümanoğlu, M., İğci, A., Cantürk,.Z., Utkan, Z., Özaslan. C. [et.al.]. (2018). Randomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: protocol mf07-01. Annals of Surgical Oncology, 25(11), 3141-3149.
dc.identifier.doi10.1245/s10434-018-6494-6
dc.identifier.endpage3149en_US
dc.identifier.issn1068-9265
dc.identifier.issue11en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage3141en_US
dc.identifier.urihttps://doi.org/10.1245/s10434-018-6494-6
dc.identifier.urihttps://hdl.handle.net/11491/1249
dc.identifier.volume25en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer New York LLC
dc.relation.ispartofAnnals of Surgical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject[Belirlenecek]en_US
dc.titleRandomized trial comparing resection of primary tumor with no surgery in stage IV breast cancer at presentation: Protocol mf07-01
dc.typeArticle

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