The association between the parenchymal neurological involvement and posterior uveitis in Behcet's syndrome

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dc.authoridSandikci, Sevinc Can / 0000-0001-5921-8029
dc.authoridBitik, Berivan / 0000-0001-5803-915X
dc.authoridTUFAN, Abdurrahman / 0000-0001-6244-9362
dc.authoridmercan, ridvan / 0000-0003-1537-2192
dc.authoridSahin, Kubilay / 0000-0002-6458-1807
dc.authorwosidSandikci, Sevinc Can / AAE-7267-2021
dc.authorwosidBitik, Berivan / AAI-9195-2021
dc.authorwosidTUFAN, Abdurrahman / A-7613-2016
dc.authorwosidmercan, ridvan / W-3342-2017
dc.contributor.authorBitik, B.
dc.contributor.authorTufan, A.
dc.contributor.authorSahin, K.
dc.contributor.authorKaradag, Y. Sucullu
dc.contributor.authorSandikci, S. Can
dc.contributor.authorMercan, R.
dc.contributor.authorHaznedaroglu, S.
dc.date.accessioned2021-11-01T14:58:20Z
dc.date.available2021-11-01T14:58:20Z
dc.date.issued2016
dc.department[Belirlenecek]
dc.description.abstractObjective. Behvet's syndrome (BS) is a systemic vasculitis, which may involve multiple organ systems simultaneously. Clinical findings in BS often fit into well-recognised patterns, such as the association between papulo-pustular skin lesions and arthritis. We have recently observed a distinct pattern, in which a subtype of neuro-Behcet's syndrome (NBS) is often preceded by specific ophthalmic manifestations of the disease process. The purpose of this study is to evaluate the association between the parenchymal subtype of NBS and posterior uveitis (PU). Methods. We retrospectively reviewed the clinical records of 295 patients with BS, who met the international classification-criteria for-BS, diagnosed at two major rheumatology clinics from 2010 to 2014. Patient demographics, ophthalmic examinations, clinical and radiologic patterns of neurological involvement were recorded. Manifestations of BS were classified as PU, NBS, vascular involvement, and arthritis. The association between clinical findings was analysed for statistical significance. Results. Of the 295 patients, 100 had PU and 44 had NBS. 30 patients had parenchymal NBS and 14 had vascular NBS. Patients with PU were significantly more likely to have neurological involvement compared to those without PU (p<0.001; odds ratio: 3.924; 95% CI: 1.786-8.621). Rate of posterior uveitis was higher in patients with parenchymal NBS when compared to patients with vascular NBS, vascular BS or arthritis (63.3%, 21.4%, 22% and 4.2% respectively, p<0.001). Conclusion. Our findings suggest a clinically and statistically significant association between posterior uveitis and parenchymal type of neurologic involvement in BS. The development of posterior uveitis in a patient with previously diagnosed BS should be recognised as a warning sign for predisposition to neurologic involvement. These patients should be informed about the possible signs and symptoms of neurological involvement, which can cause very rapid and irreversible damage unless recognised and treated immediately.
dc.identifier.endpageS85en_US
dc.identifier.issn0392-856X
dc.identifier.issn1593-098X
dc.identifier.issue6en_US
dc.identifier.pmid27791948
dc.identifier.startpageS82en_US
dc.identifier.urihttps://hdl.handle.net/11491/6601
dc.identifier.volume34en_US
dc.identifier.wosWOS:000388065900012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherClinical & Exper Rheumatology
dc.relation.ispartofClinical And Experimental Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's syndromeen_US
dc.subjectneuro-Behcet's syndromeen_US
dc.subjectposterior uveitisen_US
dc.titleThe association between the parenchymal neurological involvement and posterior uveitis in Behcet's syndrome
dc.typeArticle

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