TNF-alpha-308 G/A variant may be associated with bipolar disorder in a Turkish population

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dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorAytac, Hasan Mervan
dc.contributor.authorCiftci, Hayriye Senturk
dc.contributor.authorYazar, Menekse Sila
dc.contributor.authorOyaci, Yasemin
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2021-11-01T15:05:12Z
dc.date.available2021-11-01T15:05:12Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground: Tumor necrosis factor alpha (TNF-alpha) is a proinflammatory multifunctional cytokine produced by macrophages. A dysregulation of the immune system contribute to the pathogenesis of bipolar disorder (BD). In this study, we aimed to investigate the relationship between the TNF-alpha gene -308G/A promoter variant and the risk of BD. Methods: A total of 104 BD patients and 94 healthy controls were enrolled in the study. Genomic DNA was isolated and TNF-alpha-308G/A variant was analyzed using PCR-RFLP method. Results: TNF-alpha-308G/A variant GG genotype and G allele were more prevalent in BD patients compared to the controls (p = 0.002 and p = 0.017, respectively). The patients carrying GG genotype had a 5.927-fold higher risk of developing BD. Then, we divided patients into two groups as smokers and non-smokers. TNF-alpha-308G/A variant GA genotype was higher in non-smoker BD patients than smoker patients (p = 0.027). We found that TNF-alpha-308G/A AA genotype and A allele increased in smoker patients compared to non-smoker patients (p = 0.008, p = 0.002, respectively). Discussion: Our results provided evidence that TNF-alpha-308G/A variant may contribute to development of BD in a Turkish cohort. In addition, this variant plays a relevant role in the smoker status of BD.
dc.identifier.doi10.15761/0101-60830000000258
dc.identifier.endpage179en_US
dc.identifier.issn0101-6083
dc.identifier.issn1806-938X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85105314666
dc.identifier.scopusqualityQ4
dc.identifier.startpage176en_US
dc.identifier.urihttps://doi.org/10.15761/0101-60830000000258
dc.identifier.urihttps://hdl.handle.net/11491/7164
dc.identifier.volume47en_US
dc.identifier.wosWOS:000647554000002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherUniv Sao Paulo, Inst Psiquiatria
dc.relation.ispartofArchives Of Clinical Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBipolar disorderen_US
dc.subjecttumor necrosis factor alphaen_US
dc.subjectvarianten_US
dc.subjectPCR-RFLPen_US
dc.titleTNF-alpha-308 G/A variant may be associated with bipolar disorder in a Turkish population
dc.typeArticle

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