PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population

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dc.authoridpehlivan, sacide / 0000-0003-1272-5845
dc.authorid, pinar / 0000-0002-1605-2724
dc.authoridOyaci, Yasemin / 0000-0002-1338-0087
dc.contributor.authorNursal, Ayse Feyda
dc.contributor.authorAydin, Pinar Cetinay
dc.contributor.authorUysal, Mehmet Atilla
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorOyac, Yasemin
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2021-11-01T15:05:16Z
dc.date.available2021-11-01T15:05:16Z
dc.date.issued2020
dc.department[Belirlenecek]
dc.description.abstractBackground: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population.
dc.description.sponsorshipIstanbul University BAP-ONAPIstanbul University [47815]en_US
dc.description.sponsorshipThe study was partially supported by Istanbul University BAP-ONAP (47815) program.en_US
dc.identifier.doi10.1590/0101-60830000000235
dc.identifier.endpage74en_US
dc.identifier.issn0101-6083
dc.identifier.issn1806-938X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85087120095
dc.identifier.scopusqualityQ4
dc.identifier.startpage71en_US
dc.identifier.urihttps://doi.org/10.1590/0101-60830000000235
dc.identifier.urihttps://hdl.handle.net/11491/7204
dc.identifier.volume47en_US
dc.identifier.wosWOS:000546177700003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherUniv Sao Paulo, Inst Psiquiatria
dc.relation.ispartofArchives Of Clinical Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSubstance use disorderen_US
dc.subjectsmoking statusen_US
dc.subjectPer3en_US
dc.subjectVNTRen_US
dc.subjectPCRen_US
dc.titlePER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population
dc.typeArticle

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