Effect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort

Basit Öğe Kaydı
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorKurnaz, Selin
dc.contributor.authorPehlivan, Sacide
dc.date.accessioned2021-11-01T18:14:54Z
dc.date.available2021-11-01T18:14:54Z
dc.date.issued2018
dc.department[Belirlenecek]
dc.description.abstractIntroduction: Chronic lymphocytic leukemia (CLL) is one of the most common leukemias in developed countries. Multiple myeloma (MM), a clonal plasma cell disease, is the second most prevalent hematological cancer. Interleukin-17 (IL-17) can facilitate the secretion of numerous proinflammatory cytokines. The goal of the present study was to evalu-ate the effect of IL-17F rs763780 on CLL/MM susceptibility in a Turkish cohort. Methods: The study included 37 patients with CLL, 21 patients with MM, and 100 healthy controls. The IL-17F rs763780 variant was genoty-ped using polymerase chain reaction-restriction fragment length poly-morphism (PCR-RFLP). The frequencies of the alleles and genotypes in patient and control groups were compared by the ?2 test. Results: No significant difference was found in the distribution of ge-notypes and alleles frequencies for IL-17F rs 763780 between the pati-ents and the healthy controls (P>0.05).Conclusion: Our results suggest that IL-17 rs763780 variant may not contribute to CLL and MM pathogenesis.
dc.identifier.doi10.5152/imj.2018.58751
dc.identifier.endpage42en_US
dc.identifier.issn2619-9793
dc.identifier.issn2148-094X
dc.identifier.issue1en_US
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org10.5152/imj.2018.58751
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZM01UY3hNUT09
dc.identifier.urihttps://hdl.handle.net/11491/7565
dc.identifier.volume19en_US
dc.identifier.wosWOS:000436147800009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.relation.ispartofİstanbul Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject[No Keywords]en_US
dc.titleEffect of the IL-17F rs763780 Variant on Chronic Lymphocytic Leukemia and Multiple Myeloma Risk in a Turkish Cohort
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu