Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules

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dc.authoridMutlu, Dogukan / 0000-0003-3259-5822
dc.authorwosidMutlu, Dogukan / AAL-4976-2021
dc.contributor.authorKurt-Kizildogan, Aslihan
dc.contributor.authorOtur, Cigdem
dc.contributor.authorYilmaz, Can
dc.contributor.authorArslan, Sevki
dc.contributor.authorMutlu, Dogukan
dc.contributor.authorKivrak, Arif
dc.contributor.authorKonus, Metin
dc.date.accessioned2021-11-01T15:06:03Z
dc.date.available2021-11-01T15:06:03Z
dc.date.issued2021
dc.department[Belirlenecek]
dc.description.abstractAims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies..
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [115Z020]; Van Yuzuncu Yl University [FBA-2018-6901, FYL-2019-8301]; Pamukkale UniversityPamukkale University [PAU-BAP-2018-KRM-011]; Ondokuz Mays UniversityOndokuz Mayis University [PYO.ZRT.1904.17.053]en_US
dc.description.sponsorshipThe authors thank The Scientific and Technological Re-search Council of Turkey (Project No: 115Z020) , Van Yuzuncu Yl University (FBA-2018-6901 and FYL-2019-8301) and Pamukkale University (PAU-BAP-2018-KRM-011) and Ondokuz Mays University (PYO.ZRT.1904.17.053) for financial supporting of reactant and reagents.en_US
dc.identifier.doi10.2174/1570180817999201109203226
dc.identifier.endpage470en_US
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85116036916
dc.identifier.scopusqualityQ3
dc.identifier.startpage461en_US
dc.identifier.urihttps://doi.org/10.2174/1570180817999201109203226
dc.identifier.urihttps://hdl.handle.net/11491/7477
dc.identifier.volume18en_US
dc.identifier.wosWOS:000677488500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor[Belirlenecek]
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters In Drug Design & Discovery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIndoleen_US
dc.subjectheteroaromatic compoundsen_US
dc.subjectantioxidanten_US
dc.subjectcytotoxicityen_US
dc.subjectantimicrobialen_US
dc.subjectsmall moleculesen_US
dc.titleSynthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules
dc.typeArticle

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