Effects of potentilla fulgens as a prophylactic agent for ischemia/reperfusion injury in the rat ovary

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dc.authorid0000-0002-7869-9662
dc.authorid0000-0002-0848-9731
dc.authorid0000-0002-9668-2063
dc.contributor.authorToğrul, Cihan
dc.contributor.authorBalsak, Deniz
dc.contributor.authorEkinci, Cenap
dc.contributor.authorSeçkin, Kerem Doğa
dc.contributor.authorEkinci, Aysun
dc.contributor.authorTahaoğlu, Ali Emre
dc.contributor.authorBademkıran, Muhammed Hanifi
dc.contributor.authorGörkem, Ümit
dc.contributor.authorYaman Görük, Neval
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorDeveci, Engin
dc.contributor.authorŞeker, Uğur
dc.date.accessioned2019-05-13T08:57:51Z
dc.date.available2019-05-13T08:57:51Z
dc.date.issued2015
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractOBJECTIVE: To investigate the effects of Potentilla fulgens as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. STUDY DESIGN: A total of 32 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia+reperfusion, and (IV) I/R+Potentilla fulgens. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Group IV received 400 mg/kg/day Potentilla fulgens intraperitoneally 5 days before I/R injury. RESULTS: The detorsion group showed preantral ovarian follicles and corpus luteum around the blood vessels and positive expression of vascular endothelial growth factor (VEGF). In the Potentilla fulgens group (IV) the stromal vascular endothelium with weak expression of VEGF was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of VEGF. In the detorsion group the theca cells and apoptotic cells in preantral follicles showed positive expression of E-cadherin in the ovarian surface epithelium. Moreover, the E-cadherin expression was found to be positive in terms of follicular development, theca cells, granulosa cells, and corpus luteum. Potentilla fulgens, given after ischemic injury and apoptosis, was seen to decrease the effect of Bcl-2 expression. CONCLUSION: These results provide compelling evidence that the expression of E-cadherin in the ovary is an important component of ovarian function. © Science Printers and Publishers, Inc.
dc.identifier.citationToğrul, C., Balsak, D., Ekinci, C., Seçkin, K. D., Ekinci, A., Tahaoğlu, A. E., ... & Deveci, E. (2015). Effects of Potentilla fulgens as a Prophylactic Agent for Ischemia/Reperfusion Injury in the Rat Ovary. Analytical and quantitative cytopathology and histopathology, 37(5), 310-316.
dc.identifier.endpage316en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage310en_US
dc.identifier.urihttps://hdl.handle.net/11491/1022
dc.identifier.volume37en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherScience Printers and Publishers Inc.
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectE-Cadherinen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOvarian Torsionen_US
dc.subjectOvaryen_US
dc.subjectReperfusion Damageen_US
dc.subjectReperfusion Injuryen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectVEGFen_US
dc.titleEffects of potentilla fulgens as a prophylactic agent for ischemia/reperfusion injury in the rat ovary
dc.typeArticle

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