Design and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery

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dc.authoridGeyik, Gülcan / 0000-0003-4558-9288
dc.authorscopusid57215410631
dc.authorscopusid6506707051
dc.contributor.authorGeyik, Gülcan
dc.contributor.authorIşıklan, Nuran
dc.date.accessioned2021-11-01T14:51:33Z
dc.date.available2021-11-01T14:51:33Z
dc.date.issued2021
dc.departmentHitit Üniversitesi, Alaca Avni Çelik Meslek Yüksekokulu, Mülkiyet Koruma ve Güvenlik Bölümü
dc.description.abstractIn the last two decades, the utilization of magnetic nanospheres in intelligent polymeric structures have received increased attention of researchers in numerous biomedical applications. Here, hybrid nanostructured triple-responsive magnetic nanospheres (?-Car-g-P(AA/DMA)@Fe3O4) containing inorganic iron oxide core (Fe3O4) and organic graft copolymeric shell based on ?-carrageenan (?-Car) and poly(acrylic acid/dimethylaminoethyl methacrylate) (P(AA/DMA)) were synthesized by microwave induced co-precipitation technique. The structure, size, surface morphology, magnetic property and stability of synthesized ?-Car-g-P(AA/DMA)@Fe3O4 magnetic nanospheres were characterized using FTIR, UV, XRD, TEM, Zeta-sizer, and VSM. ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres were loaded with 5-Fluorouracil (5-FU) as an antineoplastic drug, and their 5-FU release behavior was explored in diverse graft yields, pH values, temperatures and in the existence of an alternating magnetic field. The ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres demonstrated pH-, thermo-, and magnetic field-responsive 5-FU release with good biocompatibility and excellent anticancer activity. In addition, 5-FU release under 50 mT magnetic field reached to 100% within 4 h. This work exhibits that hybrid nanospheres have a triple stimuli-responsive influence, which is of principal importance for the future design and application of multi-functional responsive platforms to develop externally stimulated release of active agents and their healthcare capability.
dc.description.sponsorship2018/055en_US
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of Kırıkkale University [Project number: 2018/055 , 2018] for their financial support.en_US
dc.description.sponsorshipThe authors are thankful to the Scientific Research Projects Coordination Unit of Kırıkkale University [Project number: 2018/055, 2018] for their financial support.en_US
dc.identifier.citationGeyik, G., & Işıklan, N. (2021). Design and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery. International Journal of Biological Macromolecules, 192, 701-715.
dc.identifier.doi10.1016/j.ijbiomac.2021.10.007
dc.identifier.endpage715en_US
dc.identifier.issn0141-8130
dc.identifier.scopus2-s2.0-85117113370
dc.identifier.scopusqualityQ1
dc.identifier.startpage701en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.10.007
dc.identifier.urihttps://hdl.handle.net/11491/6170
dc.identifier.volume192en_US
dc.identifier.wosWOS:000710184600010
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGeyik, Gülcan
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMagnetic Iron Oxideen_US
dc.subjectPoly(acrylic acid)en_US
dc.subjectPoly(dimethylaminoethyl methacrylate)en_US
dc.subjectStimuli-responsive Nanosystemen_US
dc.subjectκ-carrageenanen_US
dc.titleDesign and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery
dc.typeArticle

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