Histopathological and immunohistochemical changes in the amniotic membrane of gestational diabetic mothers

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dc.contributor.authorToğrul, Cihan
dc.contributor.authorGörkem, Ümit
dc.contributor.authorCoşkun, Buğra
dc.contributor.authorNergisli Kaşlı, Cansu Kübra
dc.contributor.authorGüngör, Tayfun
dc.contributor.authorDeveci, Engin
dc.date.accessioned2019-05-13T08:57:36Z
dc.date.available2019-05-13T08:57:36Z
dc.date.issued2017
dc.departmentHitit Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractThe aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 28-35 weeks of gestation. Gestational diabetes (n= 6) and normal amnion membrane (n= 6) for a total of 12 units were received. Amniotic membrane thickness was measured (p<0.0001) and it was significantly higher in GDM groups compared to control group. The diameter of the amniotic epithelial cell nuclei was measured (p=0.0022). Gestational diabetes results show that there was weakening between amniotic epithelial cell-cell junction. This study showed that structural changes in epithelial cells of amniotic membrane were formed due to diabetes. The membrane thickness has led to structural changes in diameter and in diabetes group cause extracellular matrix to increase, thus leading to MMP-9 expression increase eventually disrupting matrix balance. In addition, with cd44 increase angiogenesis has been induced and thought to influence material pass between fetus and mother. © 2017, Universidad de la Frontera. All rights reserved.
dc.identifier.citationToğrul, C., Görkem, Ü., Coşkun, B., Nergisli, C. K., Güngör, T., Deveci, E. (2017). Histopathological and immunohistochemical changes in the amniotic membrane of gestational diabetic mothers. International Journal of Morphology, 35(1), 184-188.
dc.identifier.doi10.4067/S0717-95022017000100030
dc.identifier.endpage188en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage184en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022017000100030
dc.identifier.urihttps://hdl.handle.net/11491/968
dc.identifier.volume35en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidad de la Frontera
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmniotic Membraneen_US
dc.subjectGestational Diabetic Mothersen_US
dc.subjectImmunohistochemical Changesen_US
dc.titleHistopathological and immunohistochemical changes in the amniotic membrane of gestational diabetic mothers
dc.title.alternativeCambios histopatológicos e inmunohistoquímicos de la membrana amniótica de madres diabéticas gestacionalesen_US
dc.typeArticle

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