Determination of pKa values of some sulfonamides by LC and LC-PDA methods in acetonitrile-water binary mixtures

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dc.contributor.authorŞanlı, Nurullah
dc.contributor.authorŞanlı, Senem
dc.contributor.authorÖzkan, Güleren
dc.contributor.authorDenizli, Adil
dc.date.accessioned2019-05-10T09:39:25Z
dc.date.available2019-05-10T09:39:25Z
dc.date.issued2010
dc.departmentHitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractAs constantes de dissociação de sete sulfonamidas antibióticas, sulfadiazina, sulfatiazol, sulfamerazina, sulfametazina, sulfamonometoxina, sulfadoxina e sulfametoxazol, foram determinadas em diferentes misturas binárias acetonitrila-água (15, 30, 40, 50% (v/v)) usando cromatografia líquida de fase reversa. Um método usando espectros de absorbância no máximo dos picos cromatográficos previamente obtidos foi também aplicado para determinar os valores de pKa . Este método pode ser aplicado a dados oriundos de equipamentos LC-UV (com detecção por arranjo de diodos, PAD) retendo todas as vantagens dos métodos LC e espectrofotométricos. Correlações lineares foram observadas quando os valores calculados de pKa das sulfonamidas em diferentes misturas de solventes foram comparados com a fração molar da acetonitrila.
dc.description.abstractThe dissociation constants of seven sulfonamide antibiotics, sulfadiazine, sulfathiazole, sulfamerazine, sulfamethazine, sulfamonomethoxine, sulfadoxine and sulfamethoxazole, have been determined in different acetonitrile-water binary mixtures (15, 30, 40, 50% v/v) by means of reversed-phase liquid chromatographic data. Also, a method based on the absorbance spectra at the maximum of chromatographic peaks previously obtained has been applied to determine the pKa values. This method can be applied to data obtained from LC-UV (photodiode array detection (PDA)) instruments and retains all the advantages of LC and spectrophotometric methods. Linear relationships were observed when the calculated pKa values of sulfonamides in different solvent mixtures were plotted against the acetonitrile molar fraction. © 2010 Sociedade Brasileira de Química.
dc.identifier.citationŞanli, N., Şanli, S., Özkan, G., & Denizlic, A. (2010). Determination of pKa values of some sulfonamides by LC and LC-PDA methods in acetonitrile-water binary mixtures. Journal of the Brazilian Chemical Society, 21(10), 1952-1960.
dc.identifier.endpage1960en_US
dc.identifier.issn0103-5053
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage1952en_US
dc.identifier.urihttps://hdl.handle.net/11491/691
dc.identifier.volume21en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiquid Chromatographyen_US
dc.subjectPDAen_US
dc.subjectPK A Valuesen_US
dc.subjectSulfonamidesen_US
dc.titleDetermination of pKa values of some sulfonamides by LC and LC-PDA methods in acetonitrile-water binary mixtures
dc.typeArticle

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